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单核细胞趋化蛋白-1（MCP-1）基因多态性作为日本 2 型糖尿病患者糖尿病视网膜病变的潜在危险因素。

Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk factor for diabetic retinopathy in Japanese patients with type 2 diabetes.

机构信息

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

出版信息

Diabetes Res Clin Pract. 2010 Jul;89(1):e9-12. doi: 10.1016/j.diabres.2010.04.006. Epub 2010 May 21.

DOI:10.1016/j.diabres.2010.04.006
PMID:20488574
Abstract

We examined the association between diabetic retinopathy and monocyte chemoattractant protein (MCP)-1 A-2518G polymorphism in 3802 Japanese type 2 diabetic subjects. The prevalence of diabetic retinopathy was higher as the number of G alleles increased, suggesting that the G allele of this polymorphism is a susceptibility allele for diabetic retinopathy.

摘要

我们在 3802 例日本 2 型糖尿病患者中研究了单核细胞趋化蛋白-1（MCP-1）A-2518G 多态性与糖尿病视网膜病变之间的关系。随着 G 等位基因数量的增加，糖尿病视网膜病变的患病率也随之升高，这表明该多态性的 G 等位基因是糖尿病视网膜病变的易感等位基因。

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