Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
J Antimicrob Chemother. 2010 Jul;65(7):1455-9. doi: 10.1093/jac/dkq171. Epub 2010 May 20.
We have evaluated the efficacy of posaconazole, itraconazole and amphotericin B in murine models of disseminated infection caused by Exophiala spp.
Immunosuppressed mice were treated with posaconazole at 10, 20 or 40 mg/kg/day orally (po), amphotericin B at 1.5 mg/kg/day intraperitoneally (ip) or itraconazole at 50 mg/kg/day po. Treatment began 1 day after infection and continued for 7 days post-infection. Two strains of each of the three most relevant clinical species, i.e. Exophiala dermatitidis, Exophiala oligosperma and Exophiala xenobiotica, were tested.
Posaconazole showed the highest efficacy in mice infected with E. dermatitidis, the only species that showed a high neurotropism, while the three drugs showed a similarly good activity against E. oligosperma and E. xenobiotica infections.
The results suggest that posaconazole may have a clinical role in the treatment of disseminated infections caused by Exophiala species, especially in those with CNS invasion.
我们评估了泊沙康唑、伊曲康唑和两性霉素 B 在播散性感染模型中的疗效，这些感染是由外瓶霉属引起的。
免疫抑制小鼠经口给予泊沙康唑 10、20 或 40mg/kg/天（po），两性霉素 B 1.5mg/kg/天腹腔内（ip）或伊曲康唑 50mg/kg/天 po。治疗从感染后第 1 天开始，持续 7 天。测试了三种最相关的临床物种（皮炎外瓶霉、少孢外瓶霉和外生外瓶霉）的每一种的两个菌株。
泊沙康唑在感染皮炎外瓶霉的小鼠中显示出最高的疗效，这是唯一一种具有高神经趋向性的物种，而三种药物对少孢外瓶霉和外生外瓶霉感染均显示出相似的良好活性。
结果表明，泊沙康唑可能在治疗外瓶霉属引起的播散性感染方面具有临床作用，特别是在那些有中枢神经系统侵袭的感染中。
