Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, Reus, Spain.
Med Mycol. 2010 Sep;48(6):853-7. doi: 10.3109/13693780903582481.
The virulence of Exophiala dermatitidis, E. oligosperma and E. xenobiotica, three of the most common members of the genus that cause human infections, was evaluated using experimental models of disseminated infection in immunocompromised mice. Exophiala dermatitidis, and to a lesser extent E. oligosperma, were the two species causing the highest mortality, while mice infected with E. xenobiotica had the lowest mortality. Tissue burden and histopathology studies demonstrated the neurotropism of E. dermatitidis, while E. oligosperma and E. xenobiotica had a limited capacity for invading brain tissue. These models could be useful for testing new therapies against Exophiala infections.
评估了导致人类感染的三个最常见属成员之一的皮炎外瓶霉、少孢外瓶霉和外生外瓶霉的毒力，使用免疫功能低下小鼠的播散性感染实验模型进行评估。皮炎外瓶霉和在较小程度上少孢外瓶霉是导致死亡率最高的两个种，而感染外生外瓶霉的小鼠死亡率最低。组织负担和组织病理学研究表明皮炎外瓶霉具有神经嗜性，而少孢外瓶霉和外生外瓶霉侵袭脑组织的能力有限。这些模型可用于测试针对外瓶霉感染的新疗法。
