Department of Radiology, New York University Hospital for Joint Diseases, New York, NY 10009, USA.
AJR Am J Roentgenol. 2010 Jun;194(6):1581-6. doi: 10.2214/AJR.09.3588.
A paradoxical association between long-term alendronate therapy and low-energy subtrochanteric femoral fractures has been recently recognized. A retrospective review of 34 such femoral fractures was performed.
Subtrochanteric femoral fractures associated with long-term alendronate therapy present with minimal trauma, may be chronic, and when incomplete may be missed. The characteristic imaging features include initial involvement and focal thickening of the lateral cortex, transverse orientation, medial beak, and superior displacement and varus angulation at the fracture site.
最近发现，长期使用阿伦膦酸盐治疗与低能量转子下股骨骨折之间存在矛盾关系。对 34 例此类股骨骨折进行了回顾性研究。
与长期使用阿伦膦酸盐治疗相关的转子下股骨骨折创伤轻微，可能为慢性，且不完全骨折可能被漏诊。其典型影像学特征包括外侧皮质的初始受累和局灶性增厚、横向走向、内侧喙突和骨折部位的向上移位及内翻成角。
