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长期服用阿仑膦酸钠的患者出现髋臼和骶骨不稳定性骨折:病例报告。

Acetabular and sacral insufficiency fractures in a patient with a long-term history of Alendronate consumption; a case report.

机构信息

Shafa Orthopedic Hospital, Iran University of Medical Science, Tehran, Iran.

Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

出版信息

BMC Musculoskelet Disord. 2023 Mar 22;24(1):211. doi: 10.1186/s12891-023-06327-8.

Abstract

BACKGROUND

Long-term Bisphosphonate consumption has been reported to be associated with the incidence of atypical or insufficiency fracture, particularly in the proximal femur. We observed a case of acetabular and sacral insufficiency fractures in a patient with a long-term history of Alendronate consumption.

CASE PRESENTATION

A 62-year-old woman was admitted with a complaint of pain in right lower limb following low-energy trauma. The patient had a history of Alendronate consumption for more than 10 years. The bone scan revealed increased radiotracer uptake in the right side of the pelvic, proximal right femur, and sacroiliac joint. The radiographs showed type 1 sacrum fracture, acetabulum fracture with femur head protrusion into the pelvis, quadrilateral surface fracture, fracture of the right anterior column, and right superior and inferior pubic fracture. The patient was treated with total hip arthroplasty.

CONCLUSION

This case highlights the concerns regarding long-term bisphosphonate therapy and its potential complications.

摘要

背景

长期使用双膦酸盐已被报道与非典型或不足够性骨折的发生相关,尤其是在股骨近端。我们观察到一例长期使用阿仑膦酸钠的患者发生了髋臼和骶骨不足够性骨折。

病例介绍

一名 62 岁女性因低能量创伤后出现右下肢疼痛而入院。该患者有超过 10 年的阿仑膦酸钠使用史。骨扫描显示右侧骨盆、右侧股骨近端和骶髂关节放射性示踪剂摄取增加。X 线片显示 1 型骶骨骨折、髋臼骨折伴股骨头突入骨盆、四边形面骨折、右侧前柱骨折和右侧上下耻骨骨折。患者接受了全髋关节置换术。

结论

本例强调了对长期双膦酸盐治疗及其潜在并发症的关注。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ac5/10031978/66ea2179c5f0/12891_2023_6327_Fig1_HTML.jpg

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