1 型糖尿病中的抗胰岛素三聚体复合物。
The anti-insulin trimolecular complex in type 1 diabetes.
机构信息
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2010 Aug;17(4):329-34. doi: 10.1097/MED.0b013e32833aba41.
PURPOSE OF REVIEW
Description of the immunologic components needed for autoimmune diabetes.
RECENT FINDINGS
The major histocompatability complex (MHC) class II molecules are the primary susceptibility genes for many autoimmune diseases, including type 1 diabetes. Understanding of the structural interaction between MHC molecules, antigenic peptides, and T-cell receptors (the three components of the trimolecular complex) has increased greatly over the past several years. The components of the anti-insulin trimolecular complex and findings that insulin is a key autoantigen in type 1 diabetes are reviewed.
SUMMARY
The anti-insulin trimolecular complex is well defined in the nonobese diabetic mouse model. Insulin and specifically, the amino acid sequence 9 to 23 of the insulin B chain, represents a primary antigenic target for islet autoimmunity in the nonobese diabetic mouse model of type 1 diabetes with a specific mutation of this peptide preventing all diabetes. Initial studies suggest the human homologs of the anti-insulin trimolecular complex may be relevant in human disease.
目的综述
描述自身免疫性糖尿病所需要的免疫成分。
最近的发现
主要组织相容性复合体（MHC）Ⅱ类分子是许多自身免疫性疾病（包括 1 型糖尿病）的主要易感基因。过去几年中，人们对 MHC 分子、抗原肽和 T 细胞受体（三分子复合物的三个组成部分）之间的结构相互作用有了很大的了解。本文综述了抗胰岛素三分子复合物的组成以及胰岛素是 1 型糖尿病关键自身抗原的发现。
总结
在非肥胖型糖尿病小鼠模型中，抗胰岛素三分子复合物得到了很好的定义。胰岛素，特别是胰岛素 B 链 9 至 23 个氨基酸序列，代表了 1 型糖尿病非肥胖型糖尿病小鼠模型中胰岛自身免疫的主要抗原性靶标，该肽段的特定突变可预防所有糖尿病。初步研究表明，抗胰岛素三分子复合物的人类同源物可能与人类疾病有关。
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