Russell D G, Medina-Acosta E, Golubev A
Dept. of Pathology, New York University Medical Center, NY 10016.
Behring Inst Mitt. 1991 Feb(88):68-79.
The protozoan parasite Leishmania exploits the lysosomal compartment of the macrophages of its vertebrate host. Given that the macrophage is capable of killing the parasite if supplied with the correct stimulus from the host's immune system, the successful continuation of the infection is in the balance. This paper examines certain aspects of the Leishmania/macrophage interplay, with particular emphasis on the nature of defined protective antigens, and of the interface between the infected macrophage and the host's immune system.
原生动物寄生虫利什曼原虫利用其脊椎动物宿主巨噬细胞的溶酶体区室。鉴于巨噬细胞如果从宿主免疫系统获得正确刺激就能够杀死寄生虫，感染能否成功持续尚难确定。本文研究了利什曼原虫与巨噬细胞相互作用的某些方面，特别强调了特定保护性抗原的性质，以及被感染巨噬细胞与宿主免疫系统之间的界面。
