豚鼠实验性皮肤利什曼病中保护性免疫的机制。II. 活化的豚鼠和小鼠巨噬细胞对不同利什曼原虫物种的选择性破坏。
Mechanisms of protective immunity in experimental cutaneous leishmaniasis of the guinea-pig. II. Selective destruction of different Leishmania species in activated guinea-pig and mouse macrophages.
作者信息
Behin R, Mauel J, Rowe D S
出版信息
Clin Exp Immunol. 1975 May;20(2):351-8.
Abstract
Macrophages activation as the effector mechanism in destroying L. enriettii in the guinea-pig, and L. tropica in the mouse, was tested in vitro. Activated guinea-pig macrophages, with enhanced anti-Listeria capacity had no effect on the survival of intracellular L. enriettii, irrespective of the antigen used. Activated mouse macrophages, on the other hand, destroyed ingested L. enriettii within 24-48 hr but had no effect on L. tropica during the same time period. It is suggested that the pathogenicity of a Leishmania parasite in a given host depends on the ability of the parasite to survive in the host's activated macrophages. The possible mechanisms by which L. enriettii evades destruction in activated guinea-pig macrophages are discussed.
摘要
在体外测试了巨噬细胞激活作为豚鼠体内消灭恩氏利什曼原虫以及小鼠体内消灭热带利什曼原虫的效应机制。具有增强抗李斯特菌能力的活化豚鼠巨噬细胞，无论使用何种抗原，对细胞内恩氏利什曼原虫的存活均无影响。另一方面，活化的小鼠巨噬细胞在24 - 48小时内可消灭摄入的恩氏利什曼原虫，但在同一时间段内对热带利什曼原虫没有作用。有人提出，利什曼原虫在特定宿主体内的致病性取决于该寄生虫在宿主活化巨噬细胞中存活的能力。文中讨论了恩氏利什曼原虫在活化豚鼠巨噬细胞中逃避破坏的可能机制。
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本文引用的文献
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Cellular immunity to Leishmania donovani in macrophages in cultures.培养物中巨噬细胞对杜氏利什曼原虫的细胞免疫。
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In vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes.经特异性致敏的淋巴细胞在体外诱导巨噬细胞产生非特异性抵抗力。
Infect Immun. 1971 Oct;4(4):337-43. doi: 10.1128/iai.4.4.337-343.1971.
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Immunological phenomena in leprosy and related diseases.麻风病及相关疾病中的免疫现象。
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Cell-mediated immunity against Besnoitia and toxoplasma in specifically and cross-immunized hamsters and in cultures.特异性免疫和交叉免疫的仓鼠及培养物中针对贝诺孢子虫和弓形虫的细胞介导免疫
J Exp Med. 1974 Mar 1;139(3):560-80. doi: 10.1084/jem.139.3.560.
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A role for activated macrophages in resistance to infection with Toxoplasma.活化巨噬细胞在抵抗弓形虫感染中的作用。
Infect Immun. 1972 Nov;6(5):829-34. doi: 10.1128/iai.6.5.829-834.1972.
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Antibody-induced movement of membrane components of Leishmania enriettii.抗体诱导的恩氏利什曼原虫膜成分运动
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The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites.刚地弓形虫与哺乳动物细胞之间的相互作用。II. 溶酶体与含有活寄生虫的吞噬泡不发生融合。
J Exp Med. 1972 Nov 1;136(5):1173-94. doi: 10.1084/jem.136.5.1173.
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Clin Exp Immunol. 1970 Sep;7(3):301-41.
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