Drover Jonathan D, Schiff Nicholas D, Victor Jonathan D
Weill Cornell Medical College of Cornell University, New York, NY, USA.
J Comput Neurosci. 2010 Jun;28(3):605-16. doi: 10.1007/s10827-010-0244-5. Epub 2010 May 20.
We develop a model of thalamocortical dynamics using a shared population of thalamic neurons to couple distant cortical regions. Behavior of the model is determined as a function of the connection strengths with shared and unshared populations in the thalamus, either within a relay nucleus or the reticular nucleus. When the coupling is via the reticular nucleus, we locate solutions of the model where distant cortical regions maintain the same activity level, and regions where one region maintains an elevated activity level, suppressing activity in the other. We locate and investigate a region where both types of solutions exist and are stable, yielding a mechanism for spontaneous changes in global activity patterns. Power spectra and coherence are computed, and marked differences in the coherence are found between the two kinds of modes. When, on the other hand, the coupling is via a shared relay nuclei, the features seen with the reticular coupling are absent. These considerations suggest a role for the reticular nucleus in modulating long distance cortical communication.
我们使用共享的丘脑神经元群体来耦合远处的皮层区域，从而构建了一个丘脑皮层动力学模型。该模型的行为取决于与丘脑内共享和非共享群体（无论是在中继核还是网状核内）的连接强度。当通过网状核进行耦合时，我们确定了模型的解，其中远处的皮层区域保持相同的活动水平，以及一个区域保持较高活动水平而抑制另一个区域活动的区域。我们确定并研究了两种类型的解都存在且稳定的区域，从而产生了一种全局活动模式自发变化的机制。计算了功率谱和相干性，发现两种模式之间的相干性存在显著差异。另一方面，当通过共享的中继核进行耦合时，网状核耦合所呈现的特征则不存在。这些考虑表明网状核在调节远距离皮层通信中发挥作用。
