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Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1.

作者信息

Keck Gary E, Poudel Yam B, Rudra Arnab, Stephens Jeffrey C, Kedei Noemi, Lewin Nancy E, Peach Megan L, Blumberg Peter M

机构信息

Department of Chemistry, University of Utah, 315 South 1400 East, Rm 2020, Salt Lake City, UT 84112, USA.

出版信息

Angew Chem Int Ed Engl. 2010 Jun 21;49(27):4580-4. doi: 10.1002/anie.201001200.

Abstract
摘要

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本文引用的文献

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New approaches to the total synthesis of the bryostatin antitumor macrolides.
Chem Asian J. 2010 Apr 1;5(4):704-54. doi: 10.1002/asia.200900634.
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Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches.
Nature. 2008 Nov 27;456(7221):485-8. doi: 10.1038/nature07543.
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Synthetic Studies Toward Bryostatin 1: Preparation of a C(1)-C(16) Fragment by Pyran Annulation.
Tetrahedron Lett. 2006 Nov 20;47(47):8267-8270. doi: 10.1016/j.tetlet.2006.09.094.
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Protein kinase C and other diacylglycerol effectors in cancer.
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Enantioselective formal total synthesis of the antitumor macrolide bryostatin 7.
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Synthetic studies toward the bryostatins: a substrate-controlled approach to the A-ring.
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