新型方法全合成苔藓抑瘤大环内酯。
New approaches to the total synthesis of the bryostatin antitumor macrolides.
机构信息
School of Chemistry & Chemical Engineering, Queen's Universty Belfast, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK.
出版信息
Chem Asian J. 2010 Apr 1;5(4):704-54. doi: 10.1002/asia.200900634.
In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune, Evans, Nishiyama and Yamamura, Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001-2009, since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.
在本次重点综述中，我们概述了各种褐藻酮的全合成。我们还讨论了各种褐藻酮类似物的合成及其生物活性。综述内容包括 Masamune、Evans、Nishiyama 和 Yamamura、Hale 和 Manaviazar、Trost、Wender、Keck、Burke、Thomas 和 Krische 的工作。我们的综述主要涵盖 2001 年至 2009 年的时间段，因为在此之前已经有详细的综述涵盖了褐藻酮全合成工作和生物学。
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