碘促进的多米诺反应在微波辐射下生成N-取代的2-氨基喹啉-3-腈。
Iodine-promoted domino reaction leading to N-substituted 2-aminoquinoline-3-carbonitriles under microwave irradiation.
作者信息
Jiang Bo, Li Chao, Tu Shu-Jiang, Shi Feng
机构信息
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, PR China.
出版信息
J Comb Chem. 2010 Jul 12;12(4):482-7. doi: 10.1021/cc1000192.
PMID:20491470
Abstract
A new iodine-promoted domino reaction of 2-aminochromene-3-carbonitriles with various isocyanates is described, and a set of polyfunctionalized N-substituted 2-aminoquinoline-3-carbonitriles with high regioselectivity were successfully synthesized under microwave heating. In this reaction, the ring-opening/recyclization process occurs unexpectedly at the ring of 4H-pyran with different isocyanates.
摘要
描述了一种新型碘促进的2-氨基苯并色烯-3-腈与各种异氰酸酯的多米诺反应，在微波加热下成功合成了一组具有高区域选择性的多官能化N-取代2-氨基喹啉-3-腈。在该反应中，4H-吡喃环与不同的异氰酸酯意外地发生开环/再环化过程。
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