易患癫痫倾向——ABCB1 基因是否发挥作用？

Predisposition to epilepsy--does the ABCB1 gene play a role?

机构信息

Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

出版信息

Epilepsia. 2010 Sep;51(9):1882-5. doi: 10.1111/j.1528-1167.2010.02588.x.

DOI:10.1111/j.1528-1167.2010.02588.x

PMID:20491876

Abstract

We performed a meta-analysis to evaluate the association between ABCB1 C3435T polymorphisms and the prevalence of epilepsy, including all relevant human studies (until June 2009), in which patients with or without epilepsy had undergone genotyping for the ABCB1 gene. Odds ratios (ORs) were calculated using a random effects model. We identified 9 case-control studies that included a total of 3,996 patients (2,454 with epilepsy and 1,542 nonepileptic subjects). No association was found between ABCB1 C3435T polymorphisms and the risk of having epilepsy (odds ratio 1.07, 95% confidence interval 0.76-1.51; p = 0.34). ABCB1 genotyping for epileptic patients is not warranted.

摘要

我们进行了一项荟萃分析，以评估 ABCB1 C3435T 多态性与癫痫患病率之间的关系，包括所有相关的人类研究（截至 2009 年 6 月），其中患有或不患有癫痫的患者均接受了 ABCB1 基因的基因分型。使用随机效应模型计算比值比（OR）。我们确定了 9 项病例对照研究，共纳入 3996 例患者（2454 例癫痫患者和 1542 例非癫痫患者）。ABCB1 C3435T 多态性与癫痫发生风险之间无关联（比值比 1.07，95%置信区间 0.76-1.51；p = 0.34）。因此，对癫痫患者进行 ABCB1 基因分型是没有必要的。