Karakoca Yeliz, Aslan Canan, Erdemir Asli Turgut, Kiremitci Ummuhan, Gurel Mehmet S, Huten Osman
Department of Dermatology, Istanbul Education and Research Hospital, Istanbul, Turkey.
Dermatol Online J. 2010 May 15;16(5):12.
Cutaneous metastasis is a relatively uncommon manifestation of visceral malignancies. It most often occurs late in the course of a disease but may also be the first presenting sign of advanced visceral cancer. The average incidence of cutaneous metastasis from a visceral neoplasm is 5.3 percent. The incidence of cutaneous metastases from carcinomas of the upper digestive tract has been reported as less than 1 percent. Cutaneous metastases of gastrointestinal tumors are usually nodular and their typical location is in the abdominal wall. A 68-year-old woman presented with a three-month history of painless nodules on the right side of her neck. Skin examination revealed two joined nodules on the right side of her neck. The nodules were skin colored, well-circumscribed, non-motile, soft, and non-tender. Histopathological examination of the skin growth revealed diffuse infiltration of the dermis and subcutaneous tissue by tumoral cells. A diagnosis of metastatic gastric carcinoma was made. However,various cutaneous metastases have been reported as erysipelas-like, zosteriform, and epidermoid cyst-like. Cutaneous metastases must always be distinguished from primary skin tumors. This report emphasizes the need for appropriate investigation of newly appearing, unusual, or persistent skin lesions such as non-healing ulcers, persistent indurated erythemas, and all skin nodules of undetermined causes.
皮肤转移是内脏恶性肿瘤相对不常见的表现形式。它最常发生在疾病进程的后期,但也可能是晚期内脏癌的首发症状。内脏肿瘤发生皮肤转移的平均发生率为5.3%。据报道,上消化道癌发生皮肤转移的发生率低于1%。胃肠道肿瘤的皮肤转移通常为结节状,典型部位在腹壁。一名68岁女性,右侧颈部出现无痛性结节3个月。皮肤检查发现右侧颈部有两个相连的结节。结节呈肤色,边界清晰,不活动,质地柔软,无压痛。对皮肤肿物进行组织病理学检查,发现肿瘤细胞弥漫浸润真皮和皮下组织。诊断为转移性胃癌。然而,各种皮肤转移曾被报道为丹毒样、带状疱疹样和表皮样囊肿样。皮肤转移必须始终与原发性皮肤肿瘤相鉴别。本报告强调,对于新出现的、不寻常的或持续存在的皮肤病变,如不愈合的溃疡、持续的硬结性红斑以及所有病因不明的皮肤结节,需要进行适当的检查。