First Department of Dermatology, Andreas Syngros Hospital, Medical School University of Athens, Greece.
Anticancer Res. 2011 Jun;31(6):2373-8.
Cutaneous metastasis of gastric adenocarcinoma is rare and usually presents in men, as nodules over the abdomen. We present the case of a woman with cutaneous metastasis of gastric adenocarcinoma showing unusual clinicopathological features.
A 37-year-old woman developed florid cutaneous metastasis over the skin of the left breast two years after total gastrectomy for a signet-ring adenocarcinoma of the diffuse type. The metastasis presented as a multinodular growth developing over erythematous skin of the left hemithorax. Microscopically, the skin tumor was predominantly made up of spindle-shaped cells, mimicking a mesenchymal/fibrohistiocytic neoplasm. A comparative immunohistochemical study of the gastric primary and the skin tumor showed an almost identical profile (keratin 7/20+; epithelial membrane antigen+, MUC-5AC+), highlighting the gastric adenocarcinoma as the origin of the skin metastasis.
Although rare, cutaneous metastases of gastric adenocarcinomas can develop in women and may mimic inflammatory metastasis of breast adenocarcinoma. Immunohistochemistry is invaluable in establishing the correct diagnosis.
胃腺癌的皮肤转移较为罕见，通常发生于男性，表现为腹部的结节。我们报告了一例女性胃腺癌皮肤转移的病例，其具有不常见的临床病理特征。
一名 37 岁女性在因弥漫型印戒细胞腺癌行全胃切除术后两年，出现了左乳房皮肤的广泛皮肤转移。转移表现为左胸上部红斑皮肤的多结节生长。显微镜下，皮肤肿瘤主要由梭形细胞组成，类似于间叶/纤维组织细胞性肿瘤。对胃原发肿瘤和皮肤肿瘤进行的免疫组织化学比较研究显示出几乎相同的特征（角蛋白 7/20+；上皮膜抗原+，MUC-5AC+），提示胃腺癌是皮肤转移的起源。
尽管罕见，但胃腺癌的皮肤转移也可能发生于女性，并且可能类似于乳腺腺癌的炎性转移。免疫组织化学在确立正确诊断方面具有重要价值。
