小鼠对化学诱导肿瘤的抗体反应。
Antibody response of mice to chemically induced tumors.
作者信息
Brown J P, Klitzman J M, Hellström I, Nowinski R C, Hellström K E
出版信息
Proc Natl Acad Sci U S A. 1978 Feb;75(2):955-8. doi: 10.1073/pnas.75.2.955.
Abstract
BALB/c mice immunized with syngeneic methylcholanthrene-induced fibrosarcomas did not have antibodies against the unique tumor-specific transplantation antigens, even though they were capable of rejecting a lethal dose of tumor cells. Endogenous murine leukemia virus antigens expressed by certain of the tumors did, however, elicit high titers of antibodies, accounting for serological crossreactions that occurred between those tumors.
摘要
用同基因甲基胆蒽诱导的纤维肉瘤免疫的BALB/c小鼠，即使能够排斥致死剂量的肿瘤细胞，也没有针对独特肿瘤特异性移植抗原的抗体。然而，某些肿瘤表达的内源性鼠白血病病毒抗原确实引发了高滴度的抗体，这解释了这些肿瘤之间发生的血清学交叉反应。
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Antibody response of mice to chemically induced tumors.小鼠对化学诱导肿瘤的抗体反应。
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Changes in tumor-specific antigen expression during passage in vitro and in vivo of newly derived methylcholanthrene-induced sarcomas of BALB/C mice.新衍生的甲基胆蒽诱导的BALB/C小鼠肉瘤在体外和体内传代过程中肿瘤特异性抗原表达的变化。
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本文引用的文献
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Immunity to methylcholanthrene-induced sarcomas.对甲基胆蒽诱导肉瘤的免疫性。
J Natl Cancer Inst. 1957 Jun;18(6):769-78.
2
In vitro studies of immune reactions against autochthonous and syngeneic mouse tumors induced by methylcholanthrene and plastic discs.针对甲基胆蒽和塑料盘诱导的同种和同基因小鼠肿瘤的免疫反应的体外研究。
Int J Cancer. 1968 Jul 15;3(4):467-82. doi: 10.1002/ijc.2910030408.
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Serologic approaches to the study of cancer in animals and in man.研究动物和人类癌症的血清学方法。
Cancer Res. 1968 Jul;28(7):1288-99.
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Serum mediated inhibition of cellular immunity to methylcholanthrene-induced murine sarcomas.血清介导的对甲基胆蒽诱导的小鼠肉瘤细胞免疫的抑制作用。
Cell Immunol. 1970 May;1(1):18-30. doi: 10.1016/0008-8749(70)90058-4.
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Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.小鼠主要组织相容性复合体的血清学定义成分和淋巴细胞定义成分。
J Exp Med. 1972 Dec 1;136(6):1430-44. doi: 10.1084/jem.136.6.1430.
7
Expression of murine leukemia virus structural antigens on the surface of chemically induced murine sarcomas.化学诱导的小鼠肉瘤表面上小鼠白血病病毒结构抗原的表达
Proc Natl Acad Sci U S A. 1974 Dec;71(12):5037-41. doi: 10.1073/pnas.71.12.5037.
8
Characterization of murine leukaemia virus-specific DNA present in normal mouse cells.正常小鼠细胞中存在的鼠白血病病毒特异性DNA的特性分析。
Nat New Biol. 1973 Jul 18;244(133):76-9. doi: 10.1038/newbio244076a0.
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Autogenous immunity to endogenous RNA tumor virus. Radioimmune precipitation assay of mouse serum antibody levels.对内源性RNA肿瘤病毒的自身免疫。小鼠血清抗体水平的放射免疫沉淀测定。
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