Department of Oncology and Pathology, Karolinska Institutet Stockholm, R8:03 CCK, Karolinska Hospital, SE 17176 Stockholm, Sweden.
Biochem Biophys Res Commun. 2010 May 21;396(1):147-51. doi: 10.1016/j.bbrc.2010.04.026.
Horizontal or lateral gene transfer is an effective mechanism for the exchange of genetic information in bacteria allowing bacterial diversification and facilitating adaptation to new environments. Recent data demonstrate that DNA may also be transferred between somatic cells via the uptake of apoptotic bodies. This process allows transfer of viral genes that have been incorporated into the genome in a receptor-independent fashion. Transferred DNA is replicated and propagated in daughter cells in cell that have an inactivated DNA response which may impact tumor progression.
水平或横向基因转移是细菌中遗传信息交换的有效机制，使细菌多样化并促进其适应新环境。最近的数据表明，DNA 也可以通过摄取凋亡小体在体细胞之间转移。这个过程允许以受体非依赖的方式将已整合到基因组中的病毒基因转移。转移的 DNA 在失活的 DNA 反应的细胞中复制和增殖，这可能会影响肿瘤的进展。
