University of Oradea, Faculty of Science, Romania.
Cancer Treat Rev. 2010 Dec;36(8):606-14. doi: 10.1016/j.ctrv.2010.04.004. Epub 2010 May 21.
The implementation of altered fractionation schedules in clinical practice came as a need to improve loco-regional control and survival in those cancer patient groups which did not respond satisfactorily to conventionally fractionated radiotherapy. The current review aims to present the radiobiological rationale behind various non-conventional treatment schedules including the encountered challenges, through a compilation of clinical studies/trials and their contribution towards therapeutic gain.
改变分割方案在临床实践中的实施是为了提高那些对常规分割放疗反应不佳的癌症患者群体的局部控制和生存率。本综述旨在通过对临床研究/试验的汇编,以及它们对治疗增益的贡献,介绍各种非常规治疗方案背后的放射生物学原理,包括所遇到的挑战。