Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
J Natl Compr Canc Netw. 2010 May;8(5):532-40; quiz 541. doi: 10.6004/jnccn.2010.0041.
Medullary thyroid cancer (MTC) is a neuroendocrine tumor derived from parafollicular or C cells of the thyroid gland. Surgical resection is the mainstay of treatment for MTC. External-beam radiation treatment (EBRT) has traditionally played a limited role in the management of MTC. Despite aggressive surgery, patients at high risk for local recurrence may benefit from adjuvant EBRT. With improvements in radiation technique, adequate dose can be effectively delivered to the region at risk while minimizing dose to surrounding critical structures. Although the role of EBRT in the management of these tumors has thus far been poorly defined, EBRT should be considered as a treatment option for patients with locally advanced MTC to optimize locoregional control.
甲状腺髓样癌（MTC）是一种神经内分泌肿瘤，来源于甲状腺滤泡旁细胞或 C 细胞。手术切除是 MTC 的主要治疗方法。外照射治疗（EBRT）在 MTC 的治疗中传统上作用有限。尽管进行了积极的手术，但局部复发风险高的患者可能受益于辅助 EBRT。随着放射技术的改进，可以有效地将足够的剂量输送到危险区域，同时最大限度地减少对周围关键结构的剂量。尽管 EBRT 在这些肿瘤的治疗中的作用迄今为止尚未明确，但对于局部晚期 MTC 患者，EBRT 应被视为一种治疗选择，以优化局部区域控制。
