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Androgen receptor responsive enhancers are flanked by consistently-positioned H3-acetylated nucleosomes.

作者信息

Berman Benjamin P, Frenkel Baruch, Coetzee Gerhard A, Jia Li

出版信息

Cell Cycle. 2010 Jun 1;9(11):2249-50. doi: 10.4161/cc.9.11.11621.

DOI:10.4161/cc.9.11.11621
PMID:20495358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4373526/
Abstract
摘要

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An androgen response element driven reporter assay for the detection of androgen receptor activity in prostate cells.一种用于检测前列腺细胞中雄激素受体活性的雄激素反应元件驱动的报告基因检测法。
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Histone H2A.Z deregulation in prostate cancer. Cause or effect?组蛋白H2A.Z在前列腺癌中的失调：原因还是结果？
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Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity.染色质可及性揭示了雄激素受体激活和转录特异性的相关见解。
Genome Biol. 2012 Oct 3;13(10):R88. doi: 10.1186/gb-2012-13-10-r88.
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Androgen receptor serine 81 mediates Pin1 interaction and activity.雄激素受体丝氨酸 81 介导 Pin1 的相互作用和活性。
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Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells.雄激素受体增强子在前列腺癌细胞中无配体时的动态核小体缺失区域。
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Control of nuclear receptor function by local chromatin structure.局部染色质结构对核受体功能的调控。
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本文引用的文献

1
Divergent transcription: a new feature of active promoters.发散转录：活跃启动子的一个新特征。
Cell Cycle. 2009 Aug 15;8(16):2557-64. doi: 10.4161/cc.8.16.9305. Epub 2009 Aug 19.
2
Histone modifications at human enhancers reflect global cell-type-specific gene expression.人类增强子上的组蛋白修饰反映了整体细胞类型特异性基因表达。
Nature. 2009 May 7;459(7243):108-12. doi: 10.1038/nature07829. Epub 2009 Mar 18.
3
Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity.由组蛋白乙酰化、共调节因子和转录能力定义的具有不同功能的基因组雄激素受体占据区域。
PLoS One. 2008;3(11):e3645. doi: 10.1371/journal.pone.0003645. Epub 2008 Nov 10.
4
Mapping short DNA sequencing reads and calling variants using mapping quality scores.使用比对质量分数比对短DNA测序读数并识别变异。
Genome Res. 2008 Nov;18(11):1851-8. doi: 10.1101/gr.078212.108. Epub 2008 Aug 19.
5
The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome.绝缘子结合蛋白CTCF在人类基因组中其结合位点周围定位20个核小体。
PLoS Genet. 2008 Jul 25;4(7):e1000138. doi: 10.1371/journal.pgen.1000138.
6
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.叉头框蛋白A1（FoxA1）将表观遗传特征转化为增强子驱动的谱系特异性转录。
Cell. 2008 Mar 21;132(6):958-70. doi: 10.1016/j.cell.2008.01.018.
7
Dynamic regulation of nucleosome positioning in the human genome.人类基因组中核小体定位的动态调控
Cell. 2008 Mar 7;132(5):887-98. doi: 10.1016/j.cell.2008.02.022.
8
Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells.复发性前列腺肿瘤细胞中全基因座染色质重塑及雄激素受体介导的转录增强
Mol Cell Biol. 2006 Oct;26(19):7331-41. doi: 10.1128/MCB.00581-06.
9
Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.雄激素受体及其共激活因子的时空募集涉及染色体环化和聚合酶追踪。
Mol Cell. 2005 Sep 2;19(5):631-42. doi: 10.1016/j.molcel.2005.07.018.
10
Androgen receptor activity at the prostate specific antigen locus: steroidal and non-steroidal mechanisms.前列腺特异性抗原基因座处的雄激素受体活性：甾体和非甾体机制。
Mol Cancer Res. 2003 Mar;1(5):385-92.