出生特征与初潮年龄：来自儿童饮食干预研究（DISC）的结果。
Birth characteristics and age at menarche: results from the dietary intervention study in children (DISC).
机构信息
Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Cancer Causes Control. 2010 Sep;21(9):1379-86. doi: 10.1007/s10552-010-9565-y. Epub 2010 May 22.
OBJECTIVE
To examine whether birth weight, birth length, and gestational age are individually associated with age at menarche.
METHODS
Analyses were conducted using data from n = 278 female participants in the Dietary Intervention Study in Children (DISC). Age at menarche was prospectively collected as part of the original DISC investigation. DISC participants self-reported birth weight, birth length, and gestational age with assistance from their mothers and other records as part of the DISC06 Follow-up Study at ages 25-29. Linear regression was used to estimate the association of birth characteristics and age at menarche.
RESULTS
Birth weight was positively associated with age at menarche (p <or= 0.01) in multiple regression analyses after controlling for BMI-for-age percentile, race and DISC treatment group. No statistically significant relationships were detected between either length or gestational age and age at menarche.
CONCLUSIONS
Higher birth weight may be associated with a modest delay in age at menarche.
目的
探讨出生体重、出生身长和胎龄是否与初潮年龄独立相关。
方法
本研究使用了儿童饮食干预研究（DISC）中 278 名女性参与者的数据进行分析。初潮年龄作为 DISC 研究的一部分进行前瞻性收集。DISC 参与者在 25-29 岁时通过自我报告、母亲和其他记录协助报告了出生体重、出生身长和胎龄，并作为 DISC06 随访研究的一部分。线性回归用于估计出生特征与初潮年龄的关系。
结果
在控制 BMI 年龄百分位、种族和 DISC 治疗组后，多变量回归分析显示出生体重与初潮年龄呈正相关（p≤0.01）。出生长度或胎龄与初潮年龄之间没有检测到统计学上显著的关系。
结论
较高的出生体重可能与初潮年龄的适度延迟有关。
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