Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr 1, D-85764 Neuherberg, Germany.
Diabetologia. 2012 Mar;55(3):681-8. doi: 10.1007/s00125-011-2410-3. Epub 2011 Dec 15.
AIMS/HYPOTHESIS: The aim of this study was to examine the association between age at menarche and prediabetes as well as diabetes, considering confounding factors and the possible mediating role of adult obesity.
This cross-sectional study analysed data on 1,503 women aged 32-81 years from the German population-based KORA (Cooperative Health Research in the Region of Augsburg, South Germany) F4 Study (2006-2008). Data were collected by standardised interviews, physical examinations, and whole blood and serum measurements, including administration of an OGTT in non-diabetic participants.
Of the 1,503 women, 226 showed a prediabetic state (impaired fasting glucose and/or impaired glucose tolerance) and 140 persons had diabetes (45 participants with previously undiagnosed diabetes and 95 with known diabetes). In Poisson regression analysis, age at menarche was significantly inversely associated with prediabetes or diabetes after adjustment for year of birth (RR 0.88; 95% CI 0.82, 0.94, p < 0.0001 per additional year of menarche) and after additional adjustment for a number of confounding factors (RR 0.88; 95% CI 0.83, 0.94, p = 0.0001). Further adjustment for current BMI slightly attenuated the association with prediabetes or diabetes (RR 0.89; 95% CI 0.83, 0.95, p = 0.0009), but the association remained clearly significant.
CONCLUSIONS/INTERPRETATION: Age at menarche seems to be inversely associated with prediabetes and diabetes independent of confounding factors including current BMI. Women at risk for diabetes might be identified by a history of young age at menarche.
目的/假设：本研究旨在探讨初潮年龄与糖尿病前期和糖尿病之间的关系，同时考虑混杂因素以及成年肥胖可能的中介作用。
这项横断面研究分析了来自德国基于人群的 KORA（德国奥格斯堡地区合作健康研究）F4 研究（2006-2008 年）的 1503 名 32-81 岁女性的数据。通过标准化访谈、体格检查以及全血和血清测量收集数据，包括对非糖尿病参与者进行 OGTT。
在 1503 名女性中，226 人表现出糖尿病前期状态（空腹血糖受损和/或葡萄糖耐量受损），140 人患有糖尿病（45 名参与者患有以前未确诊的糖尿病，95 名患有已知的糖尿病）。在泊松回归分析中，在调整出生年份后（每增加一年初潮，RR 0.88；95%CI 0.82，0.94，p < 0.0001），以及在进一步调整了许多混杂因素后（RR 0.88；95%CI 0.83，0.94，p = 0.0001），初潮年龄与糖尿病前期或糖尿病显著负相关。进一步调整当前 BMI 略微减弱了与糖尿病前期或糖尿病的关联（RR 0.89；95%CI 0.83，0.95，p = 0.0009），但关联仍然非常显著。
结论/解释：初潮年龄与糖尿病前期和糖尿病之间似乎存在负相关，独立于包括当前 BMI 在内的混杂因素。初潮年龄较晚的女性可能存在糖尿病风险。
