Gårdstedt-Berghog Jenni, Niklasson Aimon, Sjöberg Agneta, Aronson A Stefan, Pivodic Aldina, Nierop Andreas F M, Albertsson-Wikland Kerstin, Holmgren Anton
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Gynecology and Obstetrics, Halmstad Hospital, Halmstad, Sweden.
Front Pediatr. 2024 Aug 15;12:1438042. doi: 10.3389/fped.2024.1438042. eCollection 2024.
To explore the timing of menarche, postmenarcheal growth, and to investigate the impact of various variables on menarcheal age and postmenarcheal and pubertal growth.
This longitudinal community population-based study analyzed pubertal growth and menarcheal age in 793 healthy term-born Swedish girls, a subset of the GrowUpGothenburg cohort. The timing of menarche and postmenarcheal growth was related to variables from the Quadratic-Exponential-Pubertal-Stop (QEPS) growth model, birth characteristics, and parental height. Multivariable models were constructed for clinical milestones; at birth, age 7 years, pubertal growth onset, and midpuberty.
Menarche aligned with 71.6% (18.8) of the QEPS model's specific pubertal growth function, at a mean age of 13.0 (1.3) years, ranging from 8.2 to 17.2 years. Postmenarcheal growth averaged 8.0 (4.9) cm, varying widely from 0.2 to 31.1 cm, decreasing with later menarche. Significant factors associated with menarcheal age included height at 7 years, childhood body-mass index, parental height, and QEPS-derived pubertal growth variables. Multivariable models demonstrated increasing explanatory power for each milestone, explaining 1% of the variance in menarcheal age at birth, 8% at age 7 years, 44% at onset of pubertal growth, and 45% at midpuberty.
This study underscores the strong link between pubertal growth and age at menarche. Data available at start of puberty explain 44% of the variation in menarcheal age, apparent on average 3.2 years before menarche. In addition, the study shows a previously seldom noticed wide variation in postmenarcheal height gain from 0.2 to 31.1 cm.
探讨月经初潮的时间、初潮后的生长情况，并研究各种变量对月经初潮年龄以及初潮后和青春期生长的影响。
这项基于社区人群的纵向研究分析了793名足月出生的瑞典健康女孩（哥德堡成长队列的一个子集）的青春期生长和月经初潮年龄。月经初潮的时间和初潮后的生长情况与二次指数青春期停止（QEPS）生长模型、出生特征及父母身高的变量相关。针对临床里程碑构建了多变量模型，包括出生时、7岁时、青春期生长开始时和青春期中期。
月经初潮与QEPS模型特定青春期生长功能的71.6%（18.8）相符，平均年龄为13.0（1.3）岁，范围为8.2至17.2岁。初潮后生长平均为8.0（4.9）厘米，差异很大，从0.2至31.1厘米不等，初潮越晚生长越少。与月经初潮年龄相关的显著因素包括7岁时的身高、儿童期体重指数、父母身高以及QEPS衍生的青春期生长变量。多变量模型显示，每个里程碑的解释力都在增加，分别解释了出生时月经初潮年龄方差的1%、7岁时的8%、青春期生长开始时的44%以及青春期中期的45%。
本研究强调了青春期生长与月经初潮年龄之间的紧密联系。青春期开始时可得的数据解释了月经初潮年龄变异的44%，这在月经初潮前平均3.2年就很明显。此外，该研究显示初潮后身高增长从0.2至31.1厘米存在此前很少被注意到的广泛差异。
