Scremin O U, Shih T M, Corcoran K D
Veterans Affairs Medical Center, Albuquerque, NM 87108.
Brain Res Bull. 1991 Mar;26(3):353-6. doi: 10.1016/0361-9230(91)90006-6.
The effect of soman, an irreversible organophosphorus cholinesterase inhibitor, on regional cerebral blood flow and glucose utilization were studied with a double-tracer, autoradiographic technique in rats. Soman was given at a subtoxic dose of 55 micrograms/kg SC and variables were measured 45 min later. No changes in arterial blood pressure or signs of toxicity were present in the animals studied. Soman induced a pronounced increase in cerebral blood flow. This change was not accompanied by an increase in cerebral metabolism, with exception of superior colliculi. Brain regions showing the more pronounced (greater than 200% over control) increases in blood flow were motor, sensory and temporal cortex, area 18a of the occipital cortex, claustrum, inferior colliculus and cerebellum. These findings differ from those previously reported for the carbamate cholinesterase inhibitor, physostigmine, and constitute the first demonstration of cerebrovascular effects for an organophosphorus cholinesterase inhibitor, soman, at nonsymptomatic doses.
用双示踪放射自显影技术在大鼠中研究了不可逆性有机磷胆碱酯酶抑制剂梭曼对局部脑血流量和葡萄糖利用的影响。梭曼以55微克/千克的亚中毒剂量皮下注射给药，45分钟后测量各项指标。在所研究的动物中，动脉血压没有变化，也没有中毒迹象。梭曼引起脑血流量显著增加。这种变化并未伴随着脑代谢的增加，但上丘除外。脑血流量增加最为显著（比对照增加超过200%）的脑区有运动、感觉和颞叶皮质、枕叶皮质18a区、屏状核、下丘和小脑。这些发现与先前报道的氨基甲酸酯类胆碱酯酶抑制剂毒扁豆碱的结果不同，并且首次证明了在无症状剂量下，有机磷胆碱酯酶抑制剂梭曼对脑血管的影响。
