Scremin O U, Allen K, Torres C, Scremin A M
Rehabilitation Medicine and Research Services, Veterans Administration Medical Center, UNM Medical School, Albuquerque, New Mexico 87108.
Neuropsychopharmacology. 1988 Dec;1(4):297-303.
Inhibition of central nervous system cholinesterase with a single pulse of physostigmine induces a pronounced increase of blood flow in the neocortex, cingulate gyrus, claustrum, and amygdala. This phenomenon is not accompanied by an increase in energy metabolism and may help explain the effect of this drug on memory in normal humans and patients with Alzheimer's disease, as well as other conditions. In contrast, a parallel increase of blood flow and metabolism was observed in the superior colliculus, a component of the visual pathways. Prolonged administration of physostigmine lead to persistent vasodilatation in the neocortex, a lessening of this effect in cingulate gyrus, claustrum and amygdala, and an increase in primary olfactory cortex and hippocampus when compared with single pulse administration. Effects of physostigmine on glucose utilization remained essentially the same as with pulse administration.
用单脉冲毒扁豆碱抑制中枢神经系统胆碱酯酶可使新皮层、扣带回、屏状核和杏仁核的血流量显著增加。这种现象并不伴随着能量代谢的增加，这可能有助于解释该药物对正常人和阿尔茨海默病患者以及其他病症的记忆的影响。相比之下，在视觉通路的一个组成部分上丘中观察到血流量和代谢的平行增加。与单脉冲给药相比，长期给予毒扁豆碱会导致新皮层持续血管舒张，扣带回、屏状核和杏仁核的这种作用减弱，初级嗅觉皮层和海马体增加。毒扁豆碱对葡萄糖利用的影响与脉冲给药时基本相同。
