Creagh Osmar, Torres Héctor, Rodríguez Normidaris, Gatica Sebastián Rodrigo
UPR MSC, San Juan, PR.
P R Health Sci J. 2010 Jun;29(2):91-5.
Etomidate has been used since 1972 as an inductor and in maintaining anesthesia. There are multiple mechanisms that account for the biologic effects of etomidate. One of the most prominent features of this drug is that it provides anesthesia without gross changes in hemodynamic parameters. This feature allows using etomidate in patients with considerable cardiopulmonary compromise avoiding the characteristic hypotension produced by other anesthetics. The mechanism that provides the basis for its cardiovascular stability is the capacity to bind and stimulate peripheral alpha-2B adrenergic receptors with a subsequent vasoconstriction. Alterations in the function or number of these receptors may account for abnormal responses during etomidate induction.
依托咪酯自1972年起就被用作诱导剂和维持麻醉剂。依托咪酯产生生物学效应的机制有多种。该药最显著的特点之一是它能提供麻醉，而不会使血流动力学参数发生明显变化。这一特性使得依托咪酯可用于有严重心肺功能不全的患者，避免了其他麻醉剂所产生的典型低血压。为其心血管稳定性提供基础的机制是它能够结合并刺激外周α-2B肾上腺素能受体，继而引起血管收缩。这些受体功能或数量的改变可能是依托咪酯诱导期间出现异常反应的原因。
