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1
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10532-7. doi: 10.1073/pnas.1004279107. Epub 2010 May 24.
2
Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.
Curr Biol. 2010 Apr 13;20(7):582-90. doi: 10.1016/j.cub.2010.03.019. Epub 2010 Apr 1.
3
The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila.
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15810-5. doi: 10.1073/pnas.1004060107. Epub 2010 Aug 23.
4
The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth.
J Cell Sci. 2009 Jul 15;122(Pt 14):2351-9. doi: 10.1242/jcs.046482. Epub 2009 Jun 16.
5
Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.
Dev Cell. 2017 Mar 13;40(5):478-490.e3. doi: 10.1016/j.devcel.2017.02.004.
6
Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.
Curr Biol. 2010 Apr 13;20(7):573-81. doi: 10.1016/j.cub.2010.01.055. Epub 2010 Apr 1.
9
POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation.
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2150-2155. doi: 10.1073/pnas.1715165115. Epub 2018 Feb 12.
10
The WW domain protein Kibra acts upstream of Hippo in Drosophila.
Dev Cell. 2010 Feb 16;18(2):309-16. doi: 10.1016/j.devcel.2009.12.013.

引用本文的文献

1
Targeting the Hippo pathway in cancer.
Nat Rev Drug Discov. 2025 Jun 30. doi: 10.1038/s41573-025-01234-0.
4
Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth.
J Cell Biol. 2024 Dec 2;223(12). doi: 10.1083/jcb.202406119. Epub 2024 Oct 7.
6
PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity.
Cell Mol Life Sci. 2023 Oct 25;80(11):333. doi: 10.1007/s00018-023-04994-3.
7
The Interaction of Mechanics and the Hippo Pathway in .
Cancers (Basel). 2023 Oct 3;15(19):4840. doi: 10.3390/cancers15194840.
8
Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.
Dev Cell. 2023 Oct 9;58(19):1864-1879.e4. doi: 10.1016/j.devcel.2023.08.029. Epub 2023 Sep 19.
9
E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation.
Cell Death Dis. 2023 Sep 12;14(9):602. doi: 10.1038/s41419-023-06130-2.
10
Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.
J Cell Biol. 2023 May 1;222(5). doi: 10.1083/jcb.202204059. Epub 2023 Apr 18.

本文引用的文献

1
Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.
Curr Biol. 2010 Apr 13;20(7):582-90. doi: 10.1016/j.cub.2010.03.019. Epub 2010 Apr 1.
2
The WW domain protein Kibra acts upstream of Hippo in Drosophila.
Dev Cell. 2010 Feb 16;18(2):309-16. doi: 10.1016/j.devcel.2009.12.013.
3
Kibra is a regulator of the Salvador/Warts/Hippo signaling network.
Dev Cell. 2010 Feb 16;18(2):300-8. doi: 10.1016/j.devcel.2009.12.011.
5
Herding Hippos: regulating growth in flies and man.
Curr Opin Cell Biol. 2009 Dec;21(6):837-43. doi: 10.1016/j.ceb.2009.09.010. Epub 2009 Oct 19.
6
The Hippo pathway regulates apical-domain size independently of its growth-control function.
J Cell Sci. 2009 Jul 15;122(Pt 14):2360-70. doi: 10.1242/jcs.041806. Epub 2009 Jun 16.
7
From the Cover: Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering.
Proc Natl Acad Sci U S A. 2009 May 19;106(20):8284-9. doi: 10.1073/pnas.0900641106. Epub 2009 May 8.
8
Morphogen control of wing growth through the Fat signaling pathway.
Dev Cell. 2008 Aug;15(2):309-21. doi: 10.1016/j.devcel.2008.06.003.
9
Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression.
Cancer Res. 2008 Jun 1;68(11):4105-15. doi: 10.1158/0008-5472.CAN-07-6814.
10
Fat and expanded act in parallel to regulate growth through warts.
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20362-7. doi: 10.1073/pnas.0706722105. Epub 2007 Dec 12.

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