Gou Jia, Zhang Tianhao, Othmer Hans G
Department of Mathematics, University of California, Riverside, CA 92507, USA.
School of Mathematics, University of Minnesota, Minneapolis, MN 55455, USA.
Cancers (Basel). 2023 Oct 3;15(19):4840. doi: 10.3390/cancers15194840.
has emerged as an ideal system for studying the networks that control tissue development and homeostasis and, given the similarity of the pathways involved, controlled and uncontrolled growth in mammalian systems. The signaling pathways used in patterning the wing disc are well known and result in the emergence of interaction of these pathways with the Hippo signaling pathway, which plays a central role in controlling cell proliferation and apoptosis. Mechanical effects are another major factor in the control of growth, but far less is known about how they exert their control. Herein, we develop a mathematical model that integrates the mechanical interactions between cells, which occur via adherens and tight junctions, with the intracellular actin network and the Hippo pathway so as to better understand cell-autonomous and non-autonomous control of growth in response to mechanical forces.
已成为研究控制组织发育和内稳态网络的理想系统，鉴于所涉及途径的相似性，也适用于研究哺乳动物系统中受控和不受控的生长。用于构建翅盘图案的信号通路是众所周知的，并且这些通路与在控制细胞增殖和凋亡中起核心作用的Hippo信号通路相互作用。机械效应是生长控制中的另一个主要因素，但对于它们如何发挥控制作用知之甚少。在此，我们开发了一个数学模型，该模型将通过黏着连接和紧密连接发生的细胞间机械相互作用与细胞内肌动蛋白网络和Hippo通路整合在一起，以便更好地理解响应机械力时生长的细胞自主和非自主控制。
