盘基网柄菌中的Ras相关基因。
Ras-related genes in Dictyostelium discoideum.
作者信息
Robbins S M, Khosla M, Thiery R, Weeks G, Spiegelman G B
机构信息
Department of Microbiology, University of British Columbia, Vancouver, Canada.
出版信息
Dev Genet. 1991;12(1-2):147-53. doi: 10.1002/dvg.1020120123.
Dictyostelium discoideum, like other eukaryotes, has been shown to express several ras-related genes. Two gene products, Ddras and DdrasG, are highly conserved relative to the human ras proteins. Ddras is expressed at the pseudoplasmodial stage of development, whereas DdrasG is expressed in vegetative cells and during early development. In addition, Dictyostelium possesses three ras-related genes, SAS1, SAS2 and Ddrap1, whose gene products are only partially conserved relative to those of the ras genes. The expression of these three genes is also developmentally regulated.
与其他真核生物一样，盘基网柄菌已被证明可表达多种与Ras相关的基因。两种基因产物Ddras和DdrasG相对于人类Ras蛋白具有高度保守性。Ddras在发育的伪原质团阶段表达，而DdrasG在营养细胞和早期发育过程中表达。此外，盘基网柄菌拥有三个与Ras相关的基因SAS1、SAS2和Ddrap1，其基因产物相对于Ras基因的产物仅部分保守。这三个基因的表达也受到发育调控。
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