通过质谱法对蛋白酶体复合物中的跨组织多样性进行定量分析。
Quantifying cross-tissue diversity in proteasome complexes by mass spectrometry.
作者信息
Pelletier Sarah, Schuurman Karianne G, Berkers Celia R, Ovaa Huib, Heck Albert J R, Raijmakers Reinout
机构信息
Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, Utrecht, The Netherlands.
出版信息
Mol Biosyst. 2010 Aug;6(8):1450-3. doi: 10.1039/c004989a. Epub 2010 May 24.
The composition of 20S mouse proteasome complexes isolated from mice heart, kidney, liver, lung, thymus and spleen was compared using quantitative mass spectrometry. Significant variety was observed in hybrid classes of immunoproteasomes which may have implications for the use of proteasome targeted inhibitors.
使用定量质谱法比较了从小鼠心脏、肾脏、肝脏、肺、胸腺和脾脏中分离出的20S小鼠蛋白酶体复合物的组成。在免疫蛋白酶体的杂交类别中观察到显著差异，这可能对蛋白酶体靶向抑制剂的使用有影响。
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