Vakhrushev Ia M, Zagrebina E A
Eksp Klin Gastroenterol. 2010(3):18-22.
Comparative evaluation of changing in functional conditions of the small intestine in using non-selective and selective non-steroidal anti-inflammatory drugs (NSAID) was estimated. The treatment of osteoarthrosis with NSAID lasted up to 3 years and longer then 3 years. As a result of integrated investigations of 92 patients it was revealed that NSAID damage the absorption primarily in proximal area of the small intestine, however the more prolonged period of using the drugs the more severe damage to intestinal digestion both of cavitary and membranous stages of hydrolysis occur. Enteropathy develops in a less extend of expression in comparison with non-selective NSAID in using selective NSAID. New pathogenic appropriateness concerning the role of hormones in functional disturbances of the small intestine in using NSAID was proved.
对使用非选择性和选择性非甾体抗炎药（NSAID）时小肠功能状态变化的比较评估进行了估算。用NSAID治疗骨关节炎持续长达3年及超过3年。对92例患者进行综合研究的结果显示，NSAID主要损害小肠近端区域的吸收，然而药物使用时间越长，对肠道消化在水解的腔期和膜期造成的损害就越严重。与使用非选择性NSAID相比，使用选择性NSAID时肠病的表达程度较轻。证明了关于激素在使用NSAID时小肠功能紊乱中作用的新致病适宜性。
