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[一组先前病因不明的腹泻儿童和成人中隐孢子虫的出现情况]

[The occurrence of Cryptosporidium in a group of children and adults with diarrhoea of undetermined earlier aetiology].

作者信息

Rozej Wioletta, Gołab Elzbieta, Waloch Maria, Wasik Maria, Sadkowska-Todys Małgorzata, Czerwiński Michał, Dzbeński Tadeusz H

机构信息

Zakład Parazytologii Lekarskiej, Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny, Warszawa.

出版信息

Przegl Epidemiol. 2010;64(1):35-9.

Abstract

In Poland since 2002 it is required to report the cases of human cryptosporidiosis, but so far none has been recorded. The aim of this study was to present some preliminary results of a study on the incidence of Cryptosporidium as a pathogen in children and adults with diarrhoea of undetermined aetiology. In 36 out of 246 stool samples collected from hospitalized patients with diarrhoea of undetermined aetiology, invasive parasite oocysts were detected. All positive results were obtained in a group of children aged up to 4 years (47.5%). The percentage of invasion in this age group was statistically significantly higher than in the group of children aged 12 months and children over 48 months of age, which was respectively 16.2% (p = 0.0018) and 7.7% (p < or = 0.001). On the basis of Restriction Fragment Length Polymorphism (RFLP) it was found that oocysts isolated from stool samples belonged to species of Cryptosporidium parvum and/or Cryptosporidium hominis. In adults with diarrhoea, and among healthy children, no oocysts of Cryptosporidium were found. The analysis of the results demonstrated that Cryptosporidium is one of a cause of diarrhoea in young children in Poland. This is an indication for the introduction of tests for cryptosporidiosis to the schedule of routine diagnostics of gastrointestinal infections in children. This work has been partly founded by Med-Vet-Net. Workpackages 22 Met-Vet-Net is an EU-founded.

摘要

自2002年起,波兰要求报告人体隐孢子虫病病例,但迄今为止尚未有病例记录。本研究的目的是呈现一项关于隐孢子虫作为病因不明腹泻的儿童和成人病原体发病率研究的一些初步结果。在从病因不明腹泻的住院患者收集的246份粪便样本中,有36份检测到侵袭性寄生虫卵囊。所有阳性结果均出现在4岁及以下儿童组(47.5%)。该年龄组的侵袭率在统计学上显著高于12个月龄儿童组和48个月龄以上儿童组,分别为16.2%(p = 0.0018)和7.7%(p≤0.001)。基于限制性片段长度多态性(RFLP)分析发现,从粪便样本中分离出的卵囊属于微小隐孢子虫和/或人隐孢子虫物种。在腹泻成人以及健康儿童中,未发现隐孢子虫卵囊。结果分析表明,隐孢子虫是波兰幼儿腹泻的病因之一。这表明应将隐孢子虫病检测纳入儿童胃肠道感染常规诊断日程。本研究部分由Med-Vet-Net资助。工作包22 Met-Vet-Net由欧盟资助。

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