Kamińska Joanna, Hoffman-Sommer Marta, Płachta Michał
Institute of Biochemistry and Biophysics PAS, 5a Pawinskiego St., 02-106 Warsaw, Poland.
Postepy Biochem. 2010;56(1):75-82.
The trafficking of proteins in the secretory pathway is mediated by vesicles. Proteins of the p24 family are present on the membranes of secretory pathway organelles (ER, Golgi, COPI and COPII vesicles). Evidence exists showing that p24 proteins play a role in the development of Alzheimer disease, making them an interesting research subject. Their presence in the secretory pathway and their tissue-dependent expression levels suggest that p24 proteins are involved in secretion. However, their molecular function is not clear. Several potential functions have been proposed for p24 proteins: (1) that they function as receptors for selected cargo; (2) that they regulate vesicle biogenesis; (3) that they perform structural and morphogenetic functions in the secretory pathway; (4) that they are responsible for quality control of transported proteins. In this article, we provide a critical review of the postulated functions of p24 proteins.
蛋白质在分泌途径中的运输由囊泡介导。p24家族蛋白存在于分泌途径细胞器（内质网、高尔基体、COPI和COPII囊泡）的膜上。有证据表明p24蛋白在阿尔茨海默病的发展中起作用，这使其成为一个有趣的研究对象。它们在分泌途径中的存在及其组织依赖性表达水平表明p24蛋白参与了分泌过程。然而，它们的分子功能尚不清楚。针对p24蛋白提出了几种潜在功能：（1）它们作为特定货物的受体发挥作用；（2）它们调节囊泡生物发生；（3）它们在分泌途径中执行结构和形态发生功能；（4）它们负责运输蛋白的质量控制。在本文中，我们对p24蛋白的假定功能进行了批判性综述。
