Department of Chemistry, and Department of Environment and Geography, University of Manitoba, Winnipeg, MB, Canada.
Chem Res Toxicol. 2010 Jul 19;23(7):1202-6. doi: 10.1021/tx100080s.
A new chemical demethylation pathway for methylmercury under physiologically and environmentally relevant conditions is reported. The pathway involves the reaction between methylmercury and a selenoamino acid (L-selenocysteine, L-selenoglutathione, D,L-selenopenicillamine, or L-selenomethionine) via the formation of bis(methylmercuric)selenide and dimethylmercury as intermediates. The final degradation product is HgSe(s).
报道了一种在生理和环境相关条件下甲基汞的新的化学去甲基化途径。该途径涉及甲基汞与硒代氨基酸（L-硒代半胱氨酸、L-谷胱甘肽硒代半胱氨酸、D，L-青霉胺硒代半胱氨酸或 L-硒代蛋氨酸）之间的反应，通过形成双（甲基汞）硒化物和二甲基汞作为中间体。最终的降解产物是 HgSe(s)。
