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倍半萜的生物活性：具有保护酒精性胃黏膜损伤和氧化损伤作用的化合物。

Bioactivity of sesquiterpenes: compounds that protect from alcohol-induced gastric mucosal lesions and oxidative damage.

机构信息

Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, Junín 956, C1113AAD Buenos Aires, Argentina.

出版信息

Mini Rev Med Chem. 2010 Jun;10(7):615-23. doi: 10.2174/138955710791383992.

DOI:10.2174/138955710791383992
PMID:20500151
Abstract

Sesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. Dehydroleucodine, a natural sesquiterpene isolated from Artemisia douglasiana Besser, and ilicic aldehyde, a semi-synthetic sesquiterpene lactones, showed in vivo protection in ethanol-induced gastric mucosa damage. This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content.

摘要

愈创木薁型和桉烷型倍半萜内酯由于具有调节和预防氧化损伤和炎症介导的生物损伤的作用而受到关注。从 Artemisia douglasiana Besser 中分离得到的天然倍半萜烯脱氢鹅去氧胆酸和半合成倍半萜内酯伊利西醛在乙醇诱导的胃黏膜损伤中表现出体内保护作用。这种作用是通过原位胃黏膜化学发光和组织抗氧化含量来确定的。

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