Starzl T E, Francavilla A, Porter K A, Benichou J
Surg Gynecol Obstet. 1978 Apr;146(4):524-32.
All, or nearly all, of the nonhepatic splanchnic viscera were removed in dogs. In most untreated dogs, the liver cells underwent changes similar to those caused by portacaval shunt, including structural deterioration of organelles and fatty metamorphosis. The rate of division of the hepatocytes, as measured by the mitotic index and by autoradiography, was depressed as were deoxyribonucleic acid synthesis and adenylate cyclase activity. These changes were restored to, or toward, normal with the intraportal administration of commercial or purified insulin but not with glucagon or epidermal growth factor. The results of both the pathologic and biochemical studies were consistent, except for an incongruity in some of the dogs in which the colon was retained.
在狗身上切除了全部或几乎全部非肝内脏。在大多数未经治疗的狗中，肝细胞发生了类似于门腔分流所引起的变化，包括细胞器结构恶化和脂肪变性。通过有丝分裂指数和放射自显影测量的肝细胞分裂率降低，脱氧核糖核酸合成和腺苷酸环化酶活性也降低。门静脉内注射商业胰岛素或纯化胰岛素可使这些变化恢复到正常或接近正常，而注射胰高血糖素或表皮生长因子则不能。病理和生化研究的结果是一致的，但在一些保留结肠的狗中存在不一致之处。
