Chechik T, Roeder L M, Tildon J T, Poduslo S E
The Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD 21205, U.S.A.
Neurochem Int. 1987;10(1):95-9. doi: 10.1016/0197-0186(87)90179-3.
Ketone bodies serve as sources for energy and as precursors for lipid synthesis in developing brain. Whether neurons and neuroglia are equally capable of using ketone bodies during differentiation is not known. Using purified populations of neurons and astrocytes from developing rat brain and purified oligodendroglia from bovine brain, the activities for the three enzymes involved in ketone body metabolism were evaluated. Enzymatic activities were found in all three cell types. Surprisingly, astrocytes had the highest levels of activity for both 3-ketoacid-CoA transferase and acetoacetyl-CoA thiolase; these activites showed dramatic changes during development. Nonetheless, neurons, astrocytes and oligodendroglia are all quite capable of using ketone bodies as metabolic fuels.
酮体是发育中的大脑的能量来源和脂质合成的前体。目前尚不清楚神经元和神经胶质细胞在分化过程中利用酮体的能力是否相同。利用从发育中的大鼠脑中纯化得到的神经元和星形胶质细胞群体以及从牛脑中纯化得到的少突胶质细胞，对酮体代谢所涉及的三种酶的活性进行了评估。在所有三种细胞类型中均发现了酶活性。令人惊讶的是，星形胶质细胞中3-酮酸-CoA转移酶和乙酰乙酰-CoA硫解酶的活性水平最高；这些活性在发育过程中发生了显著变化。尽管如此，神经元、星形胶质细胞和少突胶质细胞都完全能够将酮体用作代谢燃料。
