Adám G, Joó F, Temesvári P, Dux E, Szerdahelyi P
Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, University Medical School, Szeged, Hungary.
Neurochem Int. 1987;10(4):529-32. doi: 10.1016/0197-0186(87)90080-5.
Kinetic parameters of the albumin transport were measured during and after an acute hypoxic insult evoked in newborn piglets by experimental bilateral pneumothorax. Adenylate cyclase activity was determined in the cerebral microvessels isolated by ultracentrifugation from different stages of brain damage. A decrease of the adenylate cyclase activity was observed in the cerebral microvessels of animals with acute hypoxic condition. However, the adenylate cyclase activity was found to be increased significantly in the microvessels during recirculation. The activation of adenylate cyclase in the microvessel wall may be of pathogenetic importance in the development of vasogenic brain oedema.
通过实验性双侧气胸诱发新生仔猪急性缺氧损伤期间及之后，测量了白蛋白转运的动力学参数。从脑损伤不同阶段通过超速离心分离的脑微血管中测定了腺苷酸环化酶活性。在急性缺氧状态的动物脑微血管中观察到腺苷酸环化酶活性降低。然而，在再灌注期间微血管中腺苷酸环化酶活性显著增加。微血管壁中腺苷酸环化酶的激活在血管源性脑水肿的发展中可能具有致病重要性。
