Dux E, Temesvári P, Szerdahelyi P, Nagy A, Kovács J, Joó F
Neuroscience. 1987 Jul;22(1):317-21. doi: 10.1016/0306-4522(87)90222-3.
As a consequence of general hypoxaemia evoked experimentally by bilateral pneumothorax, brain oedema of vasogenic type developed in newborn piglets after 4 h survival. Histamine receptor antagonists, mepyramine (H1-receptor blocker), metiamide, cimetidine and ranitidine (H2-receptor antagonists) were administered either intraperitoneally or intrathecally to check to what extent the formation of brain oedema could be reduced. Mepyramine and ranitidine decreased the accumulation of water, sodium and albumin in the parietal cortex. By measuring the concentration of histamine, the presence of a histamine pool was demonstrated in the cerebral microvessels. The results suggest that histamine, if released upon hypoxic injury from the microvascular store, can take an important part in the development of vasogenic brain oedema.
由于双侧气胸实验性诱发的全身性低氧血症，新生仔猪存活4小时后出现血管源性脑水肿。通过腹腔内或鞘内注射组胺受体拮抗剂，即美吡拉敏（H1受体阻滞剂）、甲硫米特、西咪替丁和雷尼替丁（H2受体拮抗剂），来检查脑水肿的形成能在多大程度上得到减轻。美吡拉敏和雷尼替丁减少了顶叶皮质中水、钠和白蛋白的蓄积。通过测量组胺浓度，证明脑微血管中存在组胺池。结果表明，组胺如果在缺氧损伤时从微血管储存中释放出来，可能在血管源性脑水肿的发展中起重要作用。
