Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Clin Biochem. 2010 Sep;43(13-14):1045-50. doi: 10.1016/j.clinbiochem.2010.05.008. Epub 2010 May 23.
The aim of this study was to determine age- and sex-specific pediatric reference intervals for 28 analytes on the Roche cobas 6000 analyzer.
The study was conducted at the Hospital for Sick Children in Toronto, Canada. Approximately 600 outpatient samples from a pediatric population deemed to be metabolically stable were subdivided into five age classes ranging from 0 to 20 years of age and further partitioned by gender. Reference intervals were established, after removal of samples significantly affected by hemolysis, icterus and lipemia and outlier exclusion, using the Robust statistical method to obtain the 2.5th and 97.5th percentiles.
Age (birth to 20 years of age) and gender-appropriate pediatric reference intervals for 28 analytes are reported.
These reference intervals provide the basis for clinical interpretation of laboratory results using the Roche cobas 6000 analyzer or related instrumentation/methods, provided adequate reference interval verification studies are performed.
本研究旨在确定罗氏 cobas 6000 分析仪上 28 项分析物的年龄和性别特异性儿科参考区间。
该研究在加拿大多伦多的 SickKids 医院进行。大约 600 份来自代谢稳定的儿科人群的门诊样本被分为五个年龄组，从 0 岁到 20 岁，并且根据性别进一步细分。在去除明显受到溶血、黄疸和脂血影响的样本以及剔除异常值后，使用 Robust 统计方法获得第 2.5 百分位数和第 97.5 百分位数，建立参考区间。
报告了 28 项分析物的年龄（出生至 20 岁）和性别特异性儿科参考区间。
这些参考区间为使用罗氏 cobas 6000 分析仪或相关仪器/方法进行实验室结果的临床解释提供了依据，但前提是进行了充分的参考区间验证研究。
