Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima Str. 10, 10-748 Olsztyn, Poland.
Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
Sensors (Basel). 2021 Jan 22;21(3):736. doi: 10.3390/s21030736.
Improved outcomes for many types of cancer achieved during recent years is due, among other factors, to the earlier detection of tumours and the greater availability of screening tests. With this, non-invasive, fast and accurate diagnostic devices for cancer diagnosis strongly improve the quality of healthcare by delivering screening results in the most cost-effective and safe way. Biosensors for cancer diagnostics exploiting aptamers offer several important advantages over traditional antibodies-based assays, such as the in-vitro aptamer production, their inexpensive and easy chemical synthesis and modification, and excellent thermal stability. On the other hand, electrochemical biosensing approaches allow sensitive, accurate and inexpensive way of sensing, due to the rapid detection with lower costs, smaller equipment size and lower power requirements. This review presents an up-to-date assessment of the recent design strategies and analytical performance of the electrochemical aptamer-based biosensors for cancer diagnosis and their future perspectives in cancer diagnostics.
近年来，许多类型的癌症的治疗效果得到了改善，这归因于多种因素，其中包括肿瘤的早期检测和更多的筛查测试。通过这种方式，用于癌症诊断的非侵入性、快速且准确的诊断设备通过以最具成本效益和最安全的方式提供筛查结果，极大地提高了医疗保健的质量。与基于传统抗体的检测方法相比，利用适配体的癌症诊断生物传感器具有几个重要优势，例如体外适配体的生产、低廉且易于化学合成和修饰以及出色的热稳定性。另一方面，由于电化学检测具有快速检测、成本较低、设备体积较小和功率要求较低等特点，因此电化学生物传感器能够以灵敏、准确和经济的方式进行检测。本综述介绍了电化学基于适配体的生物传感器在癌症诊断中的最新设计策略和分析性能评估，以及它们在癌症诊断中的未来前景。
