Cameron T P, Rogers-Back A M, Lawlor T E, Harbell J W, Seifried H E, Dunkel V C
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Environ Mol Mutagen. 1991;17(4):264-71. doi: 10.1002/em.2850170408.
Multifunctional acrylates are being used increasingly as replacements for solvents, and occupational and general population exposure to this structural class is expanding. Four multifunctional acrylates and acrylic acid were tested for mutagenicity in the Salmonella typhimurium and mouse lymphoma L5178Y TK+/-assays. In the Salmonella assay, two of the compounds (trimethylolpropane triacrylate and trimethylolpropane trimethacrylate) showed weakly positive results with a single tester strain (TA1535) in the presence of hamster liver S9; the other three compounds were negative. All five compounds were negative in the Salmonella assay without S9 activation. In the mouse lymphoma assay, two of the compounds (acrylic acid and ethylene glycol diacrylate) were positive in both the presence and the absence of S9, one compound was positive only in the presence of S9 (ethylene glycol dimethacrylate), and one compound was positive only in the absence of S9 (trimethylolpropane triacrylate).
多功能丙烯酸酯正越来越多地被用作溶剂的替代品，职业人群和普通人群对这类化合物的接触也在增加。对四种多功能丙烯酸酯和丙烯酸进行了鼠伤寒沙门氏菌和小鼠淋巴瘤L5178Y TK+/-试验中的致突变性测试。在沙门氏菌试验中，两种化合物（三羟甲基丙烷三丙烯酸酯和三羟甲基丙烷三甲基丙烯酸酯）在仓鼠肝S9存在的情况下，对单一测试菌株（TA1535）呈现弱阳性结果；其他三种化合物为阴性。在无S9激活的沙门氏菌试验中，所有五种化合物均为阴性。在小鼠淋巴瘤试验中，两种化合物（丙烯酸和乙二醇二丙烯酸酯）在有和无S9的情况下均呈阳性，一种化合物仅在有S9时呈阳性（乙二醇二甲基丙烯酸酯），一种化合物仅在无S9时呈阳性（三羟甲基丙烷三丙烯酸酯）。
