Lack of genotoxicity of cross-linked acrylate polymers in four short-term genotoxicity assays.
作者信息
Thompson E D, Seymour J L, Aardema M J, LeBoeuf R A, Evans B L, Cody D B
机构信息
Miami Valley Laboratories, Procter & Gamble Co., Cincinnati, OH 45239-8707.
出版信息
Environ Mol Mutagen. 1991;18(3):184-99. doi: 10.1002/em.2850180306.
PMID:1915313
Abstract
Three cross-linked polyacrylate polymers containing either methylenebis-acrylamide (MBA), trimethylolpropane triacrylate (TMPTA), or triallylamine (TAA) cross-linkers were tested for genotoxicity with the Salmonella mammalian microsome assay, the L5178Y mouse lymphoma TK +/- assay, the unscheduled DNA synthesis assay in primary cultures of rat hepatocytes, and the in vivo bone marrow cytogenetic assay. The results indicate that none of the three polymers was genotoxic in these assays.
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