INSERM, U968, Paris F-75012, France.
Development. 2010 Jun;137(12):1939-52. doi: 10.1242/dev.044511.
In most tissues, the precise control of cell migration and cell-cell interaction is of paramount importance to the development of a functional structure. Several families of secreted molecules have been implicated in regulating these aspects of development, including the Slits and their Robo receptors. These proteins have well described roles in axon guidance but by influencing cell polarity and adhesion, they participate in many developmental processes in diverse cell types. We review recent progress in understanding both the molecular mechanisms that modulate Slit/Robo expression and their functions in neural and non-neural tissue.
在大多数组织中，精确控制细胞迁移和细胞-细胞相互作用对于功能性结构的发育至关重要。几种分泌分子家族被认为参与调节这些发育方面，包括 Slit 和它们的 Robo 受体。这些蛋白质在轴突导向中具有很好的描述作用，但通过影响细胞极性和黏附，它们参与了多种不同细胞类型的发育过程。我们综述了近期在理解调节 Slit/Robo 表达的分子机制及其在神经和非神经组织中的功能方面的进展。
