从科学到实践：弥散加权磁共振成像结果能否作为生物标志物监测肾纤维化的进展？
Science to practice: Can diffusion-weighted MR imaging findings be used as biomarkers to monitor the progression of renal fibrosis?
机构信息
Institute of Diagnostic, Interventional and Pediatric Radiology Inselspital, University of Bern Freiburgstrasse 10, Bern CH-3010, Switzerland.
出版信息
Radiology. 2010 Jun;255(3):667-8. doi: 10.1148/radiol.100211.
PMID:20501704
Abstract
In an experimental murine model of unilateral ureteral obstruction, Togao et al demonstrated that diffusion-weighted (DW) magnetic resonance (MR) imaging can depict and enable monitoring of abnormal changes in the progression of renal fibrosis; because these microstructural changes are complex and multifactorial, future studies focused on their specificity should be performed before they are applied in clinical trials.
摘要
在单侧输尿管梗阻的实验性小鼠模型中，Togao 等人证明扩散加权（DW）磁共振（MR）成像可以描绘和监测肾脏纤维化进展中的异常变化；由于这些微观结构变化复杂且多因素，在将其应用于临床试验之前，应进行针对其特异性的进一步研究。
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