• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.FAS 和 FASLG 基因变异与头颈部鳞状细胞癌患者发生第二原发性恶性肿瘤的风险。
Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1484-91. doi: 10.1158/1055-9965.EPI-10-0030. Epub 2010 May 25.
2
Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.头颈部鳞状细胞癌患者凋亡变异体的部位差异作为第二原发性恶性肿瘤风险的预测指标
BMC Cancer. 2016 Feb 8;16:70. doi: 10.1186/s12885-016-2110-y.
3
Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck.参与死亡途径以及头颈鳞状细胞癌风险和进展的FAS和FAS配体基因多态性。
Clin Cancer Res. 2006 Sep 15;12(18):5596-602. doi: 10.1158/1078-0432.CCR-05-1739.
4
p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck.p14ARF 基因多态性与头颈部鳞癌患者第二原发恶性肿瘤易感性的关系。
Cancer. 2011 Mar 15;117(6):1227-35. doi: 10.1002/cncr.25605. Epub 2010 Nov 8.
5
Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck.p53 相关基因的遗传变异可使头颈部鳞癌患者易患第二原发性恶性肿瘤。
Carcinogenesis. 2013 Jul;34(7):1551-7. doi: 10.1093/carcin/bgt096. Epub 2013 Mar 18.
6
Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.p27 和 p21 的遗传变异作为头颈部指数鳞状细胞癌患者发生第二原发性恶性肿瘤风险的预测因子。
Mol Cancer. 2012 Mar 26;11:17. doi: 10.1186/1476-4598-11-17.
7
Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.p21 基因多态性与头颈部鳞癌患者索引鳞状细胞癌继发第二原发性恶性肿瘤的风险。
Carcinogenesis. 2010 Feb;31(2):222-7. doi: 10.1093/carcin/bgp279. Epub 2009 Dec 2.
8
Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck.谷胱甘肽S-转移酶基因多态性与头颈部原发性鳞状细胞癌后发生第二原发性恶性肿瘤的风险
Cancer Prev Res (Phila). 2009 May;2(5):432-9. doi: 10.1158/1940-6207.CAPR-08-0222. Epub 2009 Apr 28.
9
Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.p53 和 p73 基因的遗传变异联合增加了头颈部指数鳞状细胞癌患者发生第二原发恶性肿瘤的风险。
Cancer. 2012 Jan 15;118(2):485-92. doi: 10.1002/cncr.26222. Epub 2011 Jun 29.
10
p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck.p73基因G4C14到A4T14多态性与头颈部原发性鳞状细胞癌后发生第二原发性恶性肿瘤的风险
Int J Cancer. 2009 Dec 1;125(11):2660-5. doi: 10.1002/ijc.24570.

引用本文的文献

1
Decoding the mechanisms behind second primary cancers.解读第二原发性癌症背后的机制。
J Transl Med. 2025 Jan 24;23(1):115. doi: 10.1186/s12967-025-06151-9.
2
Genomic alterations in oral multiple primary cancers.口腔多原发癌的基因组改变。
Int J Oral Sci. 2024 Feb 18;16(1):13. doi: 10.1038/s41368-023-00265-w.
3
Identification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects.利用遗传预测模型鉴定与前列腺癌风险相关的血液蛋白生物标志物：对超过 140000 名受试者的分析。
Hum Mol Genet. 2023 Nov 3;32(22):3181-3193. doi: 10.1093/hmg/ddad139.
4
Integration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).基因共表达分析和多类 SVM 的整合，明确了决定 HTLV-1 感染向癌症（ATLL）或神经紊乱（HAM/TSP）发展的命运的功能参与者。
PLoS One. 2022 Jan 18;17(1):e0262739. doi: 10.1371/journal.pone.0262739. eCollection 2022.
5
Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome.通过NF-κB p65亚基诱导FAS和PVR表达增强神经母细胞瘤自然杀伤细胞介导的细胞溶解作用，FAS和PVR缺失与患者预后不良相关。
Cancers (Basel). 2021 Aug 29;13(17):4368. doi: 10.3390/cancers13174368.
6
Single nucleotide polymorphisms and the risk of developing a second primary cancer among head and neck cancer patients: a systematic literature review and meta-analysis.单核苷酸多态性与头颈部癌症患者发生第二原发癌的风险：系统文献回顾和荟萃分析。
BMC Cancer. 2021 Jun 2;21(1):660. doi: 10.1186/s12885-021-08335-0.
7
Susceptibility of Multiple Primary Cancers in Patients With Head and Neck Cancer: Nature or Nurture?头颈癌患者发生多原发性癌症的易感性：是天性还是后天因素？
Front Oncol. 2019 Nov 21;9:1275. doi: 10.3389/fonc.2019.01275. eCollection 2019.
8
The Integrative Method Based on the Module-Network for Identifying Driver Genes in Cancer Subtypes.基于模块网络的癌症亚型驱动基因识别的综合方法。
Molecules. 2018 Jan 24;23(2):183. doi: 10.3390/molecules23020183.
9
Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.头颈部鳞状细胞癌患者凋亡变异体的部位差异作为第二原发性恶性肿瘤风险的预测指标
BMC Cancer. 2016 Feb 8;16:70. doi: 10.1186/s12885-016-2110-y.
10
Association of promoter polymorphisms of Fas -FasL genes with development of Chronic Myeloid Leukemia.Fas - FasL基因启动子多态性与慢性髓性白血病发生的关联
Tumour Biol. 2016 Apr;37(4):5475-84. doi: 10.1007/s13277-015-4295-0. Epub 2015 Nov 13.

本文引用的文献

1
p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck.p73基因G4C14到A4T14多态性与头颈部原发性鳞状细胞癌后发生第二原发性恶性肿瘤的风险
Int J Cancer. 2009 Dec 1;125(11):2660-5. doi: 10.1002/ijc.24570.
2
Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.头颈部癌患者第二原发性肿瘤/复发的新型易感基因座：基因变异的大规模评估
Cancer Prev Res (Phila). 2009 Jul;2(7):617-24. doi: 10.1158/1940-6207.CAPR-09-0025.
3
Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck.谷胱甘肽S-转移酶基因多态性与头颈部原发性鳞状细胞癌后发生第二原发性恶性肿瘤的风险
Cancer Prev Res (Phila). 2009 May;2(5):432-9. doi: 10.1158/1940-6207.CAPR-08-0222. Epub 2009 Apr 28.
4
Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.核苷酸切除修复核心基因多态性与头颈部原发性鳞状细胞癌患者发生第二原发性恶性肿瘤的风险
Carcinogenesis. 2009 Jun;30(6):997-1002. doi: 10.1093/carcin/bgp096. Epub 2009 Apr 15.
5
Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?头颈癌发病率与吸烟流行率的关系趋势：人乳头瘤病毒相关癌症的新流行？
Cancer. 2007 Oct 1;110(7):1429-35. doi: 10.1002/cncr.22963.
6
Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer.FAS和FASL中的功能多态性导致肿瘤浸润淋巴细胞凋亡增加及乳腺癌风险升高。
Carcinogenesis. 2007 May;28(5):1067-73. doi: 10.1093/carcin/bgl250. Epub 2006 Dec 20.
7
Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck.参与死亡途径以及头颈鳞状细胞癌风险和进展的FAS和FAS配体基因多态性。
Clin Cancer Res. 2006 Sep 15;12(18):5596-602. doi: 10.1158/1078-0432.CCR-05-1739.
8
Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer.评估谷胱甘肽S-转移酶基因多态性和诱变敏感性，作为先前诊断为早期头颈癌患者发生第二原发性肿瘤的风险因素。
Cancer. 2006 Jun 15;106(12):2636-44. doi: 10.1002/cncr.21928.
9
Fas gene promoter -670 polymorphism in gynecological cancer.妇科癌症中Fas基因启动子-670多态性
Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:179-82. doi: 10.1111/j.1525-1438.2006.00505.x.
10
DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients.DNA修复基因多态性与口腔癌患者发生第二原发性肿瘤的风险及死亡率
Laryngoscope. 2005 Dec;115(12):2221-31. doi: 10.1097/01.mlg.0000183736.96004.f7.

FAS 和 FASLG 基因变异与头颈部鳞状细胞癌患者发生第二原发性恶性肿瘤的风险。

FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.

机构信息

Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1484-91. doi: 10.1158/1055-9965.EPI-10-0030. Epub 2010 May 25.

DOI:10.1158/1055-9965.EPI-10-0030
PMID:20501759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2883025/
Abstract

BACKGROUND

Single-nucleotide polymorphisms in the promoter region of the FAS and FASLG may alter the transcriptional activity of these genes. We therefore investigated the association between the FAS and FASLG polymorphisms and risk for second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN).

METHODS

We used log-rank test and Cox proportional hazard models to assess the association of the four single-nucleotide polymorphisms (FAS -1377 G > A, FAS -670 A > G, FASLG -844 C > T, and FASLG -124 A > G) with the SPM-free survival and SPM risk among 1,286 incident SCCHN patients.

RESULTS

Compared with patients having the FAS -670 AA or the FASLG -844 CC genotypes, the patients having variant genotypes of FAS -670 AG/GG or FASLG -844 CT/TT genotypes had significantly increased risk for SPM, respectively. A trend for significantly increased SPM risk with increasing number of risk genotypes of the four polymorphisms was observed in a dose-response manner. Moreover, the patients with three or four combined risk genotypes had an approximately 1.8- or 2.5-fold increased risk for developing SPM compared with patients with zero or one risk genotypes, respectively.

CONCLUSIONS

Our results suggest a modestly increased risk for SPM after index SCCHN with FAS -670 A > G and FASLG -844 C > T polymorphisms and an even greater risk for SPM with multiple combined FAS and FASLG risk genotypes.

IMPACT

The FAS and FASLG polymorphisms may serve as a susceptible marker for SCCHN patients at high SPM risk.

摘要

背景

FAS 和 FASLG 启动子区域的单核苷酸多态性可能改变这些基因的转录活性。因此，我们研究了 FAS 和 FASLG 多态性与头颈部鳞状细胞癌（SCCHN）后第二原发恶性肿瘤（SPM）风险之间的关系。

方法

我们使用对数秩检验和 Cox 比例风险模型来评估四个单核苷酸多态性（FAS-1377 G > A、FAS-670 A > G、FASLG-844 C > T 和 FASLG-124 A > G）与 SPM 无复发生存和 1286 例新发性 SCCHN 患者 SPM 风险之间的关系。

结果

与 FAS-670 AA 或 FASLG-844 CC 基因型的患者相比，FAS-670 AG/GG 或 FASLG-844 CT/TT 变异基因型的患者 SPM 风险显著增加。四种多态性的风险基因型数量增加，呈剂量反应关系，SPM 风险呈显著增加趋势。此外，与零或一个风险基因型的患者相比，具有三个或四个联合风险基因型的患者发生 SPM 的风险分别增加了约 1.8 倍或 2.5 倍。

结论

我们的结果表明，FAS-670 A > G 和 FASLG-844 C > T 多态性后 SCCHN 患者的 SPM 风险略有增加，而多个联合的 FAS 和 FASLG 风险基因型患者的 SPM 风险甚至更高。

影响

FAS 和 FASLG 多态性可作为 SPM 风险较高的 SCCHN 患者的易感标志物。