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美国高血压的患病率、知晓率、治疗率和控制率趋势,1988-2008 年。

US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008.

机构信息

Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, 1230 RT, Charleston, SC 29425, USA.

出版信息

JAMA. 2010 May 26;303(20):2043-50. doi: 10.1001/jama.2010.650.

DOI:10.1001/jama.2010.650
PMID:20501926
Abstract

CONTEXT

Hypertension is a major risk factor for cardiovascular disease and treatment and control of hypertension reduces risk. The Healthy People 2010 goal was to achieve blood pressure (BP) control in 50% of the US population.

OBJECTIVE

To assess progress in treating and controlling hypertension in the United States from 1988-2008.

DESIGN, SETTING, AND PARTICIPANTS: The National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2008 in five 2-year blocks included 42 856 adults aged older than 18 years, representing a probability sample of the US civilian population.

MAIN OUTCOME MEASURES

Hypertension was defined as systolic BP of at least 140 mm Hg and diastolic BP of at least 90 mm Hg, self-reported use of antihypertensive medications, or both. Hypertension control was defined as systolic BP values of less than 140 mm Hg and diastolic BP values of less than 90 mm Hg. All survey periods were age-adjusted to the year 2000 US population.

RESULTS

Rates of hypertension increased from 23.9% (95% confidence interval [CI], 22.7%-25.2%) in 1988-1994 to 28.5% (95% CI, 25.9%-31.3%; P < .001) in 1999-2000, but did not change between 1999-2000 and 2007-2008 (29.0%; 95% CI, 27.6%-30.5%; P = .24). Hypertension control increased from 27.3% (95% CI, 25.6%-29.1%) in 1988-1994 to 50.1% (95% CI, 46.8%-53.5%; P = .006) in 2007-2008, and BP among patients with hypertension decreased from 143.0/80.4 mm Hg (95% CI, 141.9-144.2/79.6-81.1 mm Hg) to 135.2/74.1 mm Hg (95% CI, 134.2-136.2/73.2-75.0 mm Hg; P = .02/P < .001). Blood pressure control improved significantly more in absolute percentages between 1999-2000 and 2007-2008 vs 1988-1994 and 1999-2000 (18.6%; 95% CI, 13.3%-23.9%; vs 4.1%; 95% CI, -0.5% to 8.8%; P < .001). Better BP control reflected improvements in awareness (69.1%; 95% CI, 67.1%-71.1%; vs 80.7%; 95% CI, 78.1%-83.0%; P for trend = .03), treatment (54.0%; 95% CI, 52.0%-56.1%; vs 72.5%; 95% CI, 70.1%-74.8%; P = .004), and proportion of patients who were treated and had controlled hypertension (50.6%; 95% CI, 48.0%-53.2%; vs 69.1%; 95% CI, 65.7%-72.3%; P = .006). Hypertension control improved significantly between 1988-1994 and 2007-2008, across age, race, and sex groups, but was lower among individuals aged 18 to 39 years vs 40 to 59 years (P < .001) and 60 years or older (P < .001), and in Hispanic vs white individuals (P = .004).

CONCLUSIONS

Blood pressure was controlled in an estimated 50.1% of all patients with hypertension in NHANES 2007-2008, with most of the improvement since 1988 occurring after 1999-2000. Hypertension control was significantly lower among younger than middle-aged individuals and older adults, and Hispanic vs white individuals.

摘要

背景

高血压是心血管疾病的主要危险因素,治疗和控制高血压可降低风险。《健康人民 2010 年目标》的目标是实现美国人口 50%的血压控制。

目的

评估 1988-2008 年美国高血压治疗和控制的进展。

设计、地点和参与者:国家健康和营养检查调查(NHANES)1988-1994 年和 1999-2008 年分为 5 个 2 年组,包括 42856 名年龄在 18 岁以上的成年人,代表美国平民人口的概率样本。

主要观察指标

高血压定义为收缩压至少 140mmHg,舒张压至少 90mmHg,自我报告使用抗高血压药物,或两者兼有。高血压控制定义为收缩压值低于 140mmHg,舒张压值低于 90mmHg。所有调查期均按 2000 年美国人口进行年龄调整。

结果

高血压发病率从 1988-1994 年的 23.9%(95%置信区间[CI],22.7%-25.2%)上升到 1999-2000 年的 28.5%(95%CI,25.9%-31.3%;P<.001),但在 1999-2000 年和 2007-2008 年之间没有变化(29.0%;95%CI,27.6%-30.5%;P=0.24)。高血压控制率从 1988-1994 年的 27.3%(95%CI,25.6%-29.1%)上升到 2007-2008 年的 50.1%(95%CI,46.8%-53.5%;P=0.006),高血压患者的血压从 143.0/80.4mmHg(95%CI,141.9-144.2/79.6-81.1mmHg)降至 135.2/74.1mmHg(95%CI,134.2-136.2/73.2-75.0mmHg;P=0.02/P<.001)。与 1988-1994 年和 1999-2000 年相比,1999-2000 年至 2007-2008 年之间的绝对百分比血压控制改善幅度显著增加(18.6%;95%CI,13.3%-23.9%;vs 4.1%;95%CI,-0.5%至 8.8%;P<.001)。更好的血压控制反映了意识(69.1%;95%CI,67.1%-71.1%;vs 80.7%;95%CI,78.1%-83.0%;P 趋势=0.03)、治疗(54.0%;95%CI,52.0%-56.1%;vs 72.5%;95%CI,70.1%-74.8%;P=0.004)和治疗并控制高血压患者的比例(50.6%;95%CI,48.0%-53.2%;vs 69.1%;95%CI,65.7%-72.3%;P=0.006)的改善。自 1988 年以来,高血压控制在 NHANES 2007-2008 年的所有高血压患者中估计为 50.1%,其中大部分改善发生在 1999-2000 年之后。年龄在 18 至 39 岁之间的个体比年龄在 40 至 59 岁之间(P<.001)和 60 岁或以上的个体(P<.001)以及西班牙裔与白人个体(P=0.004)的血压控制明显较低。

结论

在 NHANES 2007-2008 年,估计有 50.1%的高血压患者血压得到控制,自 1988 年以来的大部分改善发生在 1999-2000 年之后。年龄在 18 岁至 39 岁之间的个体和老年成年人以及西班牙裔与白人个体的血压控制明显较低。

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