Mahler Donald A, Selecky Paul A, Harrod Christopher G
Dartmouth Medical School, Lebanon, New Hampshire 03756-0001, USA.
Pol Arch Med Wewn. 2010 May;120(5):160-6.
Patients with advanced lung or heart disease are not generally being treated consistently and effectively for relief of dyspnea.
The aim of the paper was to review available literature and to provide consensus statements using the Delphi method relevant to the topic condition.
A panel of experts of the American College of Chest Physicians (ACCP) defined the topic condition as "dyspnea that persists at rest or with minimal activity and is distressful despite optimal therapy of advanced lung or heart disease." After a literature review, the panel developed 23 statements that were assessed for agreement/disagreement on a 5-point Likert scale using 2 rounds of the Delphi method.
For the first round of the Delphi method, the survey was sent to the 15 expert panel members. Some statements were modified if deemed appropriate. For the second round of the Delphi method, 23 statements were sent to 56 clinicians from 5 relevant specialty NetWork steering committees of the ACCP. Agreement of at least 70% was achieved for 20 of the 23 statements.
There was consensus that: patients with advanced lung or heart disease should be asked about the intensity and distress of their breathlessness; pursed-lips breathing, relaxation, oxygen for those with hypoxemia, noninvasive positive pressure ventilation, and oral/parental opioids can provide relief of dyspnea; therapies should be started with the understanding that the patient and clinician will reassess whether the specific treatments are relieving dyspnea without causing adverse effects; and it is important to communicate about palliative and end-of-life care.
晚期肺病或心脏病患者在呼吸困难缓解治疗方面通常未得到持续且有效的治疗。
本文旨在回顾现有文献,并运用德尔菲法就该主题状况提供共识声明。
美国胸科医师学会(ACCP)的一个专家小组将主题状况定义为“在休息或轻微活动时仍持续存在、且尽管对晚期肺病或心脏病进行了最佳治疗但仍令人痛苦的呼吸困难”。在文献回顾之后,该小组拟定了23条声明,并通过两轮德尔菲法以5分制李克特量表评估其是否达成一致/存在分歧。
在德尔菲法的第一轮中,调查问卷发送给了15名专家小组成员。如有必要,部分声明会进行修改。在德尔菲法的第二轮中,23条声明发送给了来自ACCP 5个相关专业网络指导委员会的56名临床医生。23条声明中有20条达成了至少70%的一致意见。
已达成的共识为:应询问晚期肺病或心脏病患者其呼吸困难的强度和痛苦程度;缩唇呼吸、放松、给低氧血症患者吸氧、无创正压通气以及口服/肠道外给予阿片类药物可缓解呼吸困难;开始治疗时应明白患者和临床医生将重新评估特定治疗是否在不引起不良反应的情况下缓解了呼吸困难;并且关于姑息治疗和临终关怀的沟通很重要。