Sridhar Nimmakayala, Lakshmi Duggirala Suguna, Goverdhan Puchchakayala
Department of Pharmacology, Pydah College of Pharmacy, East Godavari, Kakinada, Andhra Pradesh, India.
Department of Pharmacology, Vaagdevi College of Pharmacy, Hanamkonda, Telangana, India.
Indian J Pharmacol. 2015 Mar-Apr;47(2):177-80. doi: 10.4103/0253-7613.153425.
The main objective of this study is to evaluate the analgesic and anti-pyretic activities of ethanolic extracts of Justicia neesii Ramam. by different experimental models.
The analgesic activity of plant extract was evaluated against thermal and chemical stimulus induced by Eddy's hot plate and acetic acid respectively in mice. Brewer's yeast induced pyrexia was used to evaluate the antipyretic activity in rats and TAB vaccine induced pyrexia was used to evaluate the antipyretic activity in rabbits.
In the hot plate model 400 mg/kg p.o. dose of J. neesii has shown its maximal effect at 3 h. The results are significant (P < 0.05) and comparable to the values of standard drug pentazocine (30 mg/kg i.p.). In acetic acid induced writhing model 400 mg/kg p.o. of plant extracts have shown highly significant activity (P < 0.001) and better than standard drug indomethacin (10 mg/kg p.o.). The 400 mg/kg p.o. dose of plant extract has given significant results against both yeast induced pyrexia and TAB vaccine induced pyrexia (P< 0.01 and 0.05 respectively). These values are comparable to that of paracetamol 100 mg/kg p.o. standard dose.
This study shows that the ethanol extract of J. neesii has significant analgesic and antipyretic activity.
本研究的主要目的是通过不同的实验模型评估紫花爵床乙醇提取物的镇痛和解热活性。
分别采用Eddy热板法和醋酸诱导法，在小鼠身上评估植物提取物对热刺激和化学刺激的镇痛活性。采用啤酒酵母诱导大鼠发热来评估其解热活性，采用伤寒、副伤寒甲、乙三联菌苗诱导家兔发热来评估其解热活性。
在热板模型中，口服400mg/kg的紫花爵床在3小时时显示出最大效果。结果具有显著性（P<0.05），与标准药物喷他佐辛（30mg/kg腹腔注射）的值相当。在醋酸诱导的扭体模型中，口服400mg/kg的植物提取物显示出高度显著的活性（P<0.001），且优于标准药物吲哚美辛（10mg/kg口服）。口服400mg/kg的植物提取物对酵母诱导的发热和伤寒、副伤寒甲、乙三联菌苗诱导的发热均产生了显著效果（分别为P<0.01和P<0.05）。这些值与对乙酰氨基酚100mg/kg口服的标准剂量相当。
本研究表明紫花爵床乙醇提取物具有显著的镇痛和解热活性。
