Department of Chemistry and Nano Science (BK 21), Ewha Womans University, Seoul 120-750, Korea.
Chem Soc Rev. 2010 Jun;39(6):2120-35. doi: 10.1039/b925092a. Epub 2010 Mar 3.
Due to the biological importances of thiols, such as cysteine, homocysteine and glutathione, the development of optical probes for thiols has been an active research area in recent few years. This critical review focuses on the fluorescent or colorimetric sensors for thiols according to their unique mechanisms between sensors and thiols, including Michael addition, cyclization with aldehyde, cleavage of sulfonamide and sulfonate ester by thiols, cleavage of selenium-nitrogen bond by thiols, cleavage of disulfide by thiols, metal complexes-oxidation-reduction, metal complexes-displace coordination, nano-particles and others (110 references).
由于巯基（如半胱氨酸、高半胱氨酸和谷胱甘肽）在生物学上的重要性，近年来，开发用于检测巯基的光学探针一直是一个活跃的研究领域。这篇综述重点介绍了根据传感器与巯基之间的独特作用机制，用于检测巯基的荧光或比色传感器，包括迈克尔加成、与醛的环化、通过巯基断裂磺酰胺和磺酸盐酯、通过巯基断裂硒-氮键、通过巯基断裂二硫键、金属配合物的氧化还原、金属配合物的取代配位、纳米粒子等（110 篇参考文献）。
